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Title of Journal: JAMA

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Abbravation: Journal of the American Medical Association

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American Medical Association

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0002-9955

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PRELIMINARY CLINICAL EVALUATION OF THROMBIN RECOVERY TEST

Authors: L. A. Sternberger,

Publish Date: 1952/12/20
Volume: 150, Issue:16, Pages: 1591-1593
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Abstract

The laboratory diagnosis of thrombosis has been difficult because of the absence in circulating blood of the two essential products of coagulation, thrombin and fibrin. The fibrin is fixed at a local site, while the excess of thrombin formed becomes inactivated immediately by antithrombic substances. Recently a method for recovering such inactivated thrombin has been developed,1 and elevated values have been demonstrated in thrombosis produced experimentally in rabbits. The method has now been applied to patients, and the present paper reports on these clinical observations.METHODS  The recovery of thrombin is accomplished by dissociating the thrombin-antithrombin complex with alkali slightly above freezing temperature and by preventing its reassociation upon neutralization through the addition of ethyl alcohol to a final concentration of 25%. Nine milliliters of venous blood are obtained with siliconized syringes2 containing 1.0 ml. of 4% sodium citrate solution. Siliconized needles (19 gauge) are used. The plasma

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References

citation_title=The Action of Heparin, Serum Albumin (Crystalline), and Salmine on Blood-Clotting Mechanisms (In Vitro); citation_author=Ferguson , J. H.;Am. J. Physiol.; citation_year=1940; citation_volume=130; citation_issue=Oct.; citation_pages=759-770 (;

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  1. A Text-Book of the Practice of Medicine.
  2. Suicide After Restoration of Sight
  3. Psychopharmacological Screening Criteria Development Project
  4. A Nutrition Program and Teaching Outline Developed for Use in the Health Centers and Clinics of the Division of Child Hygiene
  5. Infratemporal Fossa Foreign Body
  6. Possible Role of Cytomegalovirus in Atherogenesis
  7. THEORY OF SERUM THERAPY; CONTRIBUTION FROM THE BACTERIOLOGIC LABORATORY OF THE CITY OF PHILADELPHIA.
  8. THE ERYTHROCYTE SEDIMENTATION RATE: THE ADEQUACY OF A SIMPLE TEST AND ITS PRACTICAL APPLICATION IN CLINICAL MEDICINE
  9. Experimental Investigations in Serum Allergy with Reference to the Etiology of Rheumatic Joint Diseases
  10. Grayson's Diseases of the Nose
  11. Tubal Ligation
  12. THE HUMIDITY OF SCHOOLROOMS
  13. THE PROPER MATERIAL FOR MEDICAL SOCIETIES.
  14. BERLIN
  15. Cholera in Zimbabwe
  16. Access to Care in Regionalized Health Care Systems
  17. WHAT IS FEVER?
  18. Addendum: Volunteer Opportunities Overseas
  19. LETTER FROM PARIS.
  20. References and Reviews
  21. Preexposure Prophylaxis for HIV Infection
  22. THE STUDY OF NORMALS
  23. Glucocorticoid Treatment Does Not Improve Neurological Recovery Following Cardiac Arrest
  24. The Syndrome of Chronic
  25. LONDON
  26. Septic Abortion
  27. Ker's Manual of Fevers.
  28. Open Fracture of the Olecranon
  29. TOXICITY OF METHIMAZOLE (TAPAZOLE)
  30. Chronic Osteomelitis: II. Treatment With Closed Irrigation and Suction
  31. Prognostic Significance of the Initial Electrocardiogram in Patients With Acute Myocardial Infarction
  32. Application Considered for Immunotoxin in Treatment of Graft-vs-Host Disease
  33. WHIPPLE'S DISEASE (INTESTINAL LIPODYSTROPHY) AND SERUM GLYCOPROTEINS
  34. The Surprise Party
  35. Chirurgie De La Plevre Et Du Poumon.
  36. Progress in Clinical Medicine
  37. Endemic Pleural Calcification and Mesothelioma-Reply
  38. HYPERURICEMIA
  39. Mental Retardation and Schizophrenia
  40. HEALTH FOR SALE
  41. Shakespeare and Psychiatry
  42. YELLOW FEVER AND MOSQUITOES.
  43. Immunotherapy
  44. CAMP-FOLLOWERS OF SCIENCE.
  45. Medical News
  46. Activities of the Federation of State Medical Boards of the United States
  47. Elementary General Psychology
  48. The New Vital Sign-Reply
  49. THE STERILIZATION OF SURGEONS' SANITARY PAPER CAPS
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  58. Treatment of Incised Wounds Involving Tendons
  59. THE COST OF LIVING AND ADEQUATE NUTRITION
  60. ORGANIZATION SECTION
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  69. AN UNUSUAL TWIN BIRTH: A CASE IN WHICH THE TWO HEADS WERE BORN AT THE SAME TIME
  70. A Text-Book of General Bacteriology.
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  74. Medical school uncorks alcoholism education
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  78. THE EXPERT AND THE ISSUE
  79. Do Obese Persons Mirror Thin Counterparts in Calorie Intake
  80. AIDS in South Africa
  81. Prenatal Screening for Hepatitis B-Reply
  82. Prenatal Screening for Hepatitis B-Reply
  83. BERLIN
  84. THE EFFECT OF ALCOHOL ON NATURAL IMMUNITY.
  85. Reports Warn of Primary Care Shortages
  86. Hyperosmolar Coma
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  99. THE PROFESSION'S OBJECTIONS TO GOVERNMENT REINSURANCE
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  106. WHIPPLE'S DISEASE
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  108. A Card from Secretary Atkinson.
  109. HEALTH IN THE ARMY
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  111. Current Comment
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