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Title of Journal: Arch Neurol

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Abbravation: Archives of Neurology

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Cerebral Protection by Barbiturate Anesthesia: Use After Middle Cerebral Artery Occlusion in Java Monkeys

Authors: John D. Michenfelder, James H. Milde, Thoralf M. Sundt,

Publish Date: 1976/05/01
Volume: 33, Issue:5, Pages: 345-350
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• Regional cerebral ischemia was produced in 18 Java monkeys by permanent middle cerebral artery (MCA) occlusion. All monkeys were thereafter paralyzed (pancuronium bromide, 0.05 mg/kg/hr) and sedated (diazepam, 0.1 mg/kg/hr) for a 48-hour period. Thirty minutes after MCA occlusion, pentobarbital sodium anesthesia was induced in nine of the monkeys (14 mg/kg) and maintained for 48 hours (7 mg/kg every two hours), with continuous supportive care. After 48 hours, all drugs were discontinued; the monkeys were observed for five days, and then killed. Seven of the control monkeys developed a cerebral infarction, three did not survive past the 48 hours of intensive care, and the other four had a notable neurologic deficit. All pentobarbital monkeys survived the seven days, but four had a cerebral infarction and two of these had a notable neurologic deficit. These differences were statistically significant.



citation_title=Cerebral apoplexy (stroke): Pathogenesis, pathophysiology and therapy as illustrated by regional blood flow measurements in the brain; citation_author=Paulson OB;Stroke; citation_year=1971; citation_volume=2; citation_pages=327-360;

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