Microcoaxial Needle Sensor for Polarographic Measu

Authors: H Baumgärtl D W Lübbers

Publish Date: 1983

Volume: , Issue: , Pages: 37-65

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Abstract

With the progress in polarographic analysis and with the development of various types of needle sensors in vivo determination of oxygen supply to tissue has become feasible 1015 1921 23 43 56 57 6870 75 77 The smallest types of these polarographic oxygen sensors POS have tip diameters of 15 μmTheir spatial and temporal resolutions are sufficiently high for satisfactory measurement of intercapillary oxygen partial pressure p rmO rm2 4 11‚ 24 2932 40 49 52 67 However POS of this size may still cause considerable damage to the tissue To avoid structural damages and to allow almost punctiform measurements of p rmO rm2 in the cellular range further miniaturizing has been desirable For this purpose the techniques and materials used so far have proved insufficient Aside from poor polarogram characteristics increasing instability of the measuring signal sensitivity to mechanical pressure high residual currents intolerable drift of calibration curves reduced stability as well as insufficient insulation resistance and relatively high ionic sensitivity of the glass shaft of the sensor were observed

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