Journal Title
Title of Journal:
|
|
|
Publisher
Springer, Boston, MA
|
|
|
|
|
|
Authors: Keith T Muir
Publish Date: 1984
Volume: , Issue: , Pages: 415-417
Abstract
For many drugs there is a high correlation between the concentration of drug in serum and clinical reponse Optimal therapy with these drugs requires exceeding a minimal effective concentration below which no adequate response is seen while remaining below a maximal allowable concentration above which drug toxicity becomes evident Thus a dose may be chosen quite rationally by the use of a desired serum concentration as the “therapeutic” end point However it is not possible to give the same dosage to all patients a dose which proves effective in one patient will be ineffective in some and even toxic in others This is because the dosage required to achieve serum concentrations within a certain frequently narrow range is confounded by variations in the way in which different individuals distribute and eliminate drugs
Keywords:
.
|
Other Papers In This Journal:
|