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Springer, Boston, MA

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10.1002/chin.200045027

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ShortChain Fatty Acids

Authors: John L Rombeau Scott A Kripke R Gregg Settle
Publish Date: 1990
Volume: , Issue: , Pages: 317-337
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Abstract

The shortchain fatty acids SCFA also called the volatile fatty acids VFA are the C1–6 organic fatty acids These are formed in the gastrointestinal tract of mammals by microbial fermentation of carbohydrates Wolin 1981 Wrong 1981 Cummings and Branch 1986 Acetate propionate and butyrate account for 83 of SCFA so formed Nyman and Aso 1982 Demigné and Remesy 1985 and are produced in a nearly constant molar ratio 60 25 15 respectively Cummings and Branch 1986 Among their various properties SCFA are readily absorbed by intestinal mucosa Cummings et al 1987 are relatively high in caloric content Yang et al 1970 are readily metabolized by intestinal epithelium and liver Cummings 1981 stimulate sodium and water absorption in the colon Roediger and Rae 1982 and are trophic to intestinal mucosa Sakata 1987 Kripke et al 1988d


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