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Title of Journal: Arch Dermatol

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Abbravation: Archives of Dermatology

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American Medical Association

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10.1007/bf00945712

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0003-987X

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n-Alkanes in the Skin-Reply

Authors: Peter M. Elias, Mary L. Williams,

Publish Date: 1991/11/01
Volume: 127, Issue:11, Pages: 1728-1728
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Abstract

In Reply.—  In their comments on our earlier editorial,1 Küster et al provide further valuable information that may help to resolve the issue regarding the endogenous-vs-exogenous origin of epidermal n-alkanes. They now provide biochemical data on two phenotypic subgroups of autosomal recessive ichthyosis, which do not differ in their content of n-alkanes, although the alkane content of both subsets was greater than the normal subsets. We agree with the authors that photodensitometric quantitation underestimates n-alkanes of shorter chain lengths due to the volatilization of shorter chain n-alkanes during the charring procedure. Since approximately half of scale n-alkanes will have a chain length less than or equal to C25,2 the true values for n-alkanes in both of their subgroups as well as in their normal subgroups are likely to be considerably higher. Thus, we believe that laboratories that rely solely on photodensitometry


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References

citation_title=Transfer of topically applied tetracycline in various vehicles; citation_author=Johnson R, Nusbaum BP. Horwitz SN, Frost P;Arch Dermatol.; citation_year=1983; citation_volume=119; citation_pages=660-663;


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