Journal Title
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Publisher
Springer, Dordrecht
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Authors: Eric W Lee L J Wei David A Amato Sue Leurgans
Publish Date: 1992
Volume: , Issue: , Pages: 237-247
Abstract
The Cox regression model has been used extensively to analyze survival data For data that consist of large numbers of small groups of correlated failure time observations we show that the standard maximum partial likelihood estimate of the regression coefficient in the Cox model is still consistent and asymptotically normal However the corresponding standard variancecovariance estimate may no longer be valid due to the dependence among members in the groups In this article a correct variancecovariance estimate that takes account of the intragroup correlation is proposed Power comparisons are performed to show the advantage of the new proposal Examples are provided for illustration
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