Microbial Nickel Metabolism

Authors: Robert P Hausinger

Publish Date: 1993

Volume: , Issue: , Pages: 181-201

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Abstract

As described in Chapters 3–6 four nickeldependent enzymes have been isolated and characterized from various microorganisms—urease hydrogenase CO dehydrogenase and methyl coenzyme M reductase In addition specific accessory proteins have been identified as being involved in the functional incorporation of nickel ion into urease and hydrogenase Intracellular nickel processing functions may also be needed for nickel metallocenter assembly in CO dehydrogenase and for the synthesis of the nickelcontaining coenzyme F430 a component of methyl coenzyme M reductase These aspects of microbial nickel metabolism will not be repeated here Rather this chapter will focus on nickel ion transport into the microbial cell nickel ion toxicity and resistance mechanisms in microbes and other features related to microbial nickel metabolism

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