Journal Title
Title of Journal:
|
|
|
Publisher
Springer, Boston, MA
|
|
|
|
|
|
Authors: Y Tasaki Y Kotake Y Makino S Ohta M Hirobe
Publish Date: 1995
Volume: , Issue: , Pages: 599-604
Abstract
Recently there have been many reports in which 1234tetrahydroisoquinoline TIQ derivatives may be related to the onset of Parkinson’s disease1–12 In these reports we have already confirmed that TIQ and 1methylTIQ 1MeTIQ were detected in the brains of mice rats and humans and the 1MeTIQ content in the parkinsonian brain was decreased in comparison with that in a normal subject’s brain though the TIQ content was not changed in between both brains12813 In addition pretreatment with 1MeTIQ perfectly prevented mice treated with TIQ or 1methyl4phenyl1236tetrahydropyridineMPTP from bradykinesia one of the characteristic symptoms in Parkinson’s disease The slight difference in the structure between 1MeTIQ and TIQ which is whether it has a methyl group at one position or not induces a reverse effect Figure 1
Keywords:
.
|
Other Papers In This Journal:
|