Journal Title
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Publisher
Springer, Boston, MA
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Authors: James M Ford JinMing Yang William N Hait
Publish Date: 1996
Volume: , Issue: , Pages: 3-38
Abstract
Clinical drug resistance to chemo therapeutic agents is a major obstacle for their curative potential in the treatment of human cancers Multidrug resistance MDR is an important mechanism of cellular resistance to the cytotoxic activity of certain chemotherapeutic agents Tumor cells selected for the MDR phenotype overexpress the mdr1 gene product Pglycoprotein Pgp a membranebound drug efflux pump that confers resistance to a broad range of commonly used chemotherapeutic drugs and other agents Numerous compounds have been identified that inhibit the efflux activity of Pgp and reverse cellular resistance to cytotoxic agents in experimental systems 1 This suggests that clinical drug resistance in human tumors which often overexpress Pgp may be potentially overcome through the concomitant administration to patients of a Pgp inhibitor with chemotherapeutic drugs
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