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Publisher
Springer, Dordrecht
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Authors: Aristotel Pappelis Sidney W Fox
Publish Date: 1996
Volume: , Issue: , Pages: 157-165
Abstract
The Thermal ProteinFirst Paradigm describes activities of protocells and metaprotocells within the Domain Protolife The biological information that enabled protolife activities was derived by thermal proteins through selfordering of amino acids during the polymer syntheses generally by melting amino acids including aspartic acid glutamic acid or both in a copolymerization reaction The transfer of information in this activity resulted in the first genetic system when thermal proteins in contact with water selforganized to form protocells the smallest units of protolife Polypeptide and polynucleotide syntheses have been demonstrated to occur within photophosphorylating protocells We infer coevolution of these products within protocells ultimately yielded informed DNA and DNA storage transfer and gene expression mechanisms ie Central Dogma for contemporary molecular biology evolved from DNA that had little biological information The protocells exhibited traits of the last common ancestors of prokaryotic cells Without mRNAs to regenerate them in ribosomal protein synthesis thermal proteins were replaced as information molecules enzymes and structural units
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