Dichotic Listening before and after Fluoxetine Tre

Authors: Gerard E Bruder Michael W Otto Patrick J McGrath Jonathan W Stewart Maurizio Fava Jerrold F Rosenbaum Frederic M Quitkin

Publish Date: 1996/08

Volume: 15, Issue: 2, Pages: 171-

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Abstract

Thank you for visiting naturecom You are using a browser version with limited support for CSS To obtain the best experience we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer In the meantime to ensure continued support we are displaying the site without styles and JavaScriptDespite the wide variance in therapeutic response to antidepressants there are few clinical or biological predictors of treatment outcome Studies have suggested the possible value of dichotic listening measures of perceptual asymmetry PA as predictors of treatment response This study examined the relation between outcome of fluoxetine treatment and performance on verbal and nonverbal dichotic tests As part of a multisite study 86 outpatients with major depression were tested on dichotic fusedwords and complextones tests both before and during treatment Fluoxetine responders differed from nonresponders in having greater rightear lefthemisphere advantage for dichotic words and less leftear righthemisphere advantage for complex tones There was no change in PA during fluoxetine treatment which indicates that PA differences between treatment responders and nonresponders are stable trait characteristics An aggregate characteristic PA measure was the best predictor of responder status in a logistic regression analysis Findings from two clinical centers support the hypothesis that a characteristic tendency for relatively greater leftthan righthemispheric activation during dichotic listening is associated with better outcome of fluoxetine treatment

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