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Title of Journal: Arch Dermatol

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Abbravation: Archives of Dermatology

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American Medical Association

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DOI

10.1002/jcd.1013

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0003-987X

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Comparative Percutaneous Absorption of Lindane and Permethrin

Authors: Thomas J. Franz, Paul A. Lehman, Susan F. Franz, Jere D. Guin,

Publish Date: 1996/08/01
Volume: 132, Issue:8, Pages: 901-905
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Abstract

Background and Design:  Because of the concern for potential neurotoxic effects (central nervous system excitation, convulsions) in the treatment of scabies using 1% lindane lotion, 5% permethrin cream has been suggested as an alternative scabicide. Using the finite dose technique, in vitro percutaneous absorption of 5% permethrin cream or 1% lindane lotion was measured in human and guinea pig skin following a single application. In vivo blood and brain levels of the scabicides were measured in guinea pigs following three daily applications of 5% permethrin cream or 1% lindane lotion. Permethrin and lindane levels were quantified by gas chromatography/mass spectroscopy.Results:  In vitro percutaneous absorption of the two scabicides was identical in guinea pig skin; however, human skin was 20-fold more permeable to lindane than to permethrin. In vivo guinea pig blood and brain levels of lindane were fourfold greater than permethrin levels.


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References

citation_title=A photostable pyrethroid; citation_author=Elliot M, Farnham AW, Janes NF, et al;Nature.; citation_year=1973; citation_volume=246; citation_pages=169-170;


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