Effect of lipo prostaglandin E1 in ductusdependen

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Publish Date: 1998/12

Volume: 7, Issue: 01, Pages: 14-17

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Abstract

Prostaglandin E1 incorporated in lipid microspheres lipo PGE1 was administered to 42 infants with ductusdependent congenital heart disease CHD At the onset of infusion the patients were 5 hours to 141 days old mean 190 days The dose of lipo PGE1 was initially 5 ng/kg/minute The infusion continued for 1–1008 hours mean 2132 hours Lipo PGE1 was effective in 34 of the 42 patients 810 In the 8 patients in whom lipo PGE1 was not effective the ductus arteriosus had closed before initiation of infusion In all patients but one in whom the preparation was effective 33/34 the response was observed within 12 hours after the initiation of the infusion Only mild side effects such as low grade apnea and fever were observed in 7 of the 42 patients In 8 patients who received lipo PGE1 infusion for a long period more than 200 hours the effect continued for more than 4 days after the termination of infusion In the patients who received PGE1 CD the effect disappeared less than 9 hours after discontinuation of administration These findings indicate that lipo PGE1 was effective at a lower dose with a low incidence of side effects and a long duration of action Lipo PGE1 was considered to be useful and safe in patients with ductusdependent CHD

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