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Publisher
Springer, Boston, MA
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Authors: Kwang Sik Kim
Publish Date: 2000
Volume: , Issue: , Pages: 47-59
Abstract
Bacterial meningitis still results in a high mortality and morbidity despite advances in antimicrobial chemotheraphy and supportive care Durand et al 1993 Unhanand et al 1993 Both clinical and experimental data indicate limited efficacy with antimicrobial chemotherapy alone Kim 1985 McCracken et al 1984 A major contributing factor is the incomplete understanding of the pathogenesis and pathophysiology associated with the bacterial meningitis For example most cases of bacterial meningitis develop as a result of hematogenous spread but it is not clear how circulating bacteria cross the bloodbrain barrier We have utilized Ecoli as a paradigm to examine how circulating bacteria traverse the bloodbrain barrier In addition E coli is the most common gramnegative bacterium that causes meningitis particularly during the neonatal period Our investigations have become feasible with the availability of both in vitro and in vivo models of the bloodbrain barrier
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