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Title of Journal: Anal Bioanal Chem

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Abbravation: Analytical and Bioanalytical Chemistry

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Springer-Verlag

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DOI

10.1007/bf03044515

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1618-2650

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LC-APCI-MS-MS methodology for determination of glybenclamide in human plasma

Authors: Mirian R. L. Moura, Gilberto de Nucci, Susanne Rath, Felix G. R. Reyes,

Publish Date: 2003/11/05
Volume: 378, Issue:2, Pages: 499-503
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Abstract

A liquid chromatographic/atmospheric pressure chemical ionization tandem mass spectrometric method (LC-APCI-MS-MS) for the determination of glybenclamide in human plasma is described. Glypizide, an analogue of glybenclamide, was used as internal standard. The analyte was extracted from plasma with diethyl ether/dichloromethane (70:30 v/v). The chromatography uses C18 and 0.01 mol L−1 acetic acid/acetonitrile (20:80 v/v) as stationary and mobile phase, respectively. Quantitation was preformed by using multiple reaction monitoring (MRM) of the precursor ion (m/z 494.2→368.8) and the related product ion (m/z 446.0→347.3) using the internal standard method. The analytical curve was linear in the range 1–300 ng mL−1, and for a 400-μL sample of human plasma, the limit of determination of the method was 1 ng mL−1. The coefficients of variation of the method for intra-assay (within-run precision) and inter-assay (between-run precision) were less than 10%. The method was shown to be suitable for pharmacokinetic studies.


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