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Title of Journal: Am J Hypertens

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Abbravation: American Journal of Hypertension

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Effect of Sodium on Blood Pressure, Cardiac Hypertrophy, and Angiotensin Receptor Expression in Rats

Authors: Zhu, Zhiming, Zhu, Shanjun, Wu, Ziqian, Liu, Daoyan, Yang, Yongjian, Wang, Xianmei, Zhu, Jijin, Tepel, Martin,

Publish Date: 2004/01/01
Volume: 17, Issue:1, Pages: 21-24
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Zhiming Zhu, Shanjun Zhu, Ziqian Wu, Daoyan Liu, Yongjian Yang, Xianmei Wang, Jijin Zhu, Martin Tepel, Effect of Sodium on Blood Pressure, Cardiac Hypertrophy, and Angiotensin Receptor Expression in Rats, American Journal of Hypertension, Volume 17, Issue 1, January 2004, Pages 21–24, rats were exposed to low and high sodium diet for 8 weeks. Angiotensin II receptor mRNA, abundance of p38 mitogen-activated protein kinase (p38MAPK), vasoconstriction of aortic rings, and angiotensin II-induced calcium increase were investigated.Several observations suggested that cardiac hypertrophy is dependent on pressure and volume overload.1 High sodium intake has been shown to produce left ventricular hypertrophy.2,3 Several mediators may contribute to the development of cardiac hypertrophy including angiotensin II. Angiotensin II regulates electrolyte balance, induces vasoconstriction, and enhances blood pressure (BP). Angiotensin II is a potent vasoconstrictor and growth factor, primarily acting through angiotensin II receptor type 1 (AT1 receptor). After binding of angiotensin II to the AT1 receptor, several signaling pathways are activated.4,5 Components of the stress-responsive signaling pathway, p38 mitogen-activated protein kinase (p38MAPK), have been proposed to be involved in cardiac hypertrophic responses.6The investigation conforms with the guide for the care and use of laboratory animals and was approved by the local ethics committee. Male 7-week-old Wistar rats weighing 200 to 250 g were used. The rats were housed under a 12-h/12-h day/night cycle. Rats were divided randomly into groups. Rats were fed a high sodium diet (8% NaCl) without (n = 10) and with administration of nitrendipine (1 mg/kg/d; n = 10) or a low sodium diet (0.8% NaCl, n = 10), respectively. Systolic BP (tail-cuff method) and body weights were measured every week. At the end of 8 weeks, the rats were killed by decapitation and hearts and aorta were used for measurements.The thoracic aorta was dissected, carefully freed of connective tissue, and placed in Krebs’ solution, containing: NaCl 120 mmol/L, CaCl2 2.5 mmol/L, KCl 5.6 mmol/L, MgSO4 1.2 mmol/L, NaHCO3 25 mmol/L, NaH2PO4 1.2 mmol/L, D-glucose 5.5 mmol/L, equilibrated with 95% O2/5% CO2, pH 7.4, at 37°C. Isometric force of the aortic ring was measured using a force transducer connected with a polygraph (model AD Instrument, Power Lab, Australia). The aortic rings were equilibrated for 60 min. The resting tension was set to 2 g. Angiotensin II (100 nmol/L) were added and the contractions of the rings were measured.



citation_title=Intracellular ionic consequences of dietary salt loading in essential hypertension. Relation to blood pressure and effects of calcium channel blockade; citation_author=Resnick LM; citation_author=Gupta RK; citation_author=DiFabio B; citation_author=Barbagallo M; citation_author=Mann S; citation_author=Marion R; citation_author=Laragh JH; citation_journal_title=J Clin Invest; citation_year=1994; citation_volume=94; citation_pages=1269-1276;

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Other Papers In This Journal:

  1. Effect of Sodium on Blood Pressure
  3. P-132: Chronic cocaine abuse as a cause of left ventricular hypertrophy?
  4. P-405: Prevalence of asymptomatic coronary artery disease in men with vasculogenic erectile dysfunction: A prospective angiographic study
  5. P-554: Pulse pressure as a predictor factor for survival in patients with acute ishaemic stroke
  6. P-322: Impact of ambulatory pulse pressure and office pulse pressure on left ventricular hypertrophy in patients with essential hypertension
  7. G19Superiority of 3d VS 2d echocardiography for measurement of left ventricular mass: an in vivo canine anatomic validation.
  8. P-269: Correlation between ascending aortic pressures and outcomes in patients with coronary artery disease
  9. P-403: Effect of short-term supplementation of potassium chloride and potassium citrate on blood pressure in patients with untreated essential hypertension
  10. P-403: Effect of short-term supplementation of potassium chloride and potassium citrate on blood pressure in patients with untreated essential hypertension
  11. Arterial compliance changes in diabetic normotensive patients after angiotensin-converting enzyme inhibition therapy
  12. G10Cardiovascular reactivity to mental stress task and serum lipid levels in young mildly hypertensive subjects?
  13. Evaluation of antihypertensive therapy with the combination of olmesartan medoxomil and hydrochlorothiazide
  14. G34Effects of a restricted sleep regimen on ambulatory blood pressure monitoring in normotensive subjects
  15. Effect of recombinant human erythropoietin therapy on ambulatory blood pressure in normotensive and in untreated borderline hypertensive hemodialysis patients
  16. Retinol-Binding Protein and Transferrin in UrineNew Markers of Renal Function in Essential Hypertension and White Coat Hypertension?
  17. P-397: Hypertension awareness
  18. P-481: Dopaminergic dilatation on cholinergic and electric induced contractions of rat isolated tracheal muscle
  19. P-298: Screening of adolescent hypertension
  20. P-80: Diabetic masked hypertension: risk for stroke in Japanese
  21. Role of Aldosterone in Left Ventricular Hypertrophy in Hypertension
  22. An Extra-adrenal Abdominal Pheochromocytoma Causing Ectopic ACTH Syndrome
  23. P-190: The effect of accupril on circadian blood pressure patterns in hypertensive subjects with left ventricle hypertrophy
  24. P-238: Heart rate variability and ECG changes in 148 Danish patients after two years in the VALUE trial

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