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Title of Journal: Eur Arch Otorhinolaryngol

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Abbravation: European Archives of Oto-Rhino-Laryngology and Head & Neck

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Histological features and malignant transformation of inverted papilloma

Authors: Georg Eggers, Henrike Eggers, Nicola Sander, Friedrich Kößling, Reinhard Chilla,

Publish Date: 2004/07/17
Volume: 262, Issue:4, Pages: 263-268
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Inverted papilloma (IP) is a primarily benign epithelial neoplasm with a propensity to transform to squamous cell carcinoma (SCC). Neither the etiology of IP nor the factors responsible for malignant transformation are fully known to date. A considerable number of histopathological grading systems have been suggested. It was the aim of this study to find histological parameters in IP that allow a prognosis concerning the occurrence of malignant transformation. In a group of 93 cases of IP, the patients’ records, histological specimens and a questionnaire were evaluated. Thirteen patients had suffered a recurrence of a previously treated IP. SCC in the IP had been diagnosed in 12 of the cases. The histological specimen showed increased counts of mitosis and dyscariosis in the IP. All other histological parameters did not show a significant difference between the groups. History and symptoms proved to be nonspecific as well. Patients in the group with SCC were significantly older at the first diagnosis of IP than patients without carcinoma. This group also included a higher portion of male patients. Patients fulfilling the named histological criteria combined with male gender and higher age are a high-risk group in the necessary long-term follow-up.



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Other Papers In This Journal:

  1. Comparison of the result of consolidative technique otoplasty and incisionless otoplasty in the repairs of prominent ears
  2. Evaluation of ApneaGraph in the diagnosis of sleep-related breathing disorders
  3. Osteopathia striata with cranial sclerosis and hearing loss
  4. Silent sinus syndrome an acquired condition and the essential role of otorhinolaryngologist consultation: a retrospective study
  5. Differences in Mucociliary activity of volunteers undergoing Ramadan versus Nineveh fasting
  6. A schwannoma mimicing hypopharyngeal carcinoma
  7. Evaluation of hearing in patients with familial Mediterranean fever
  8. Clinical analysis of extranodal non-Hodgkin's lymphoma in the sinonasal tract
  9. RETRACTED ARTICLE: Peroral endoscopic removal: as a minimally invasive long-term surgical treatment of a regurgitated giant polisegmented fibrovascular polyp of the esophagus
  10. Occupation and cancer of the larynx: a systematic review and meta-analysis
  11. Extended lateral thoracic fasciocutaneous biosynthetic flap for reconstruction of full-thickness partial external ear defects: an experimental study
  12. A trans-well-based cellular model for the rapid pre-evaluation of tympanic membrane repair materials
  13. Lateral sphenoid sinus recess cerebrospinal fluid leak: a case series
  14. External septal reconstruction with the use of polydioxanone foil: our experience
  15. Microbial colonization of tracheoesophageal voice prostheses (Provox2) following total laryngectomy
  16. No benefit for regional control and survival by planned neck dissection in primary irradiated oropharyngeal cancer irrespective of p16 expression
  17. No benefit for regional control and survival by planned neck dissection in primary irradiated oropharyngeal cancer irrespective of p16 expression
  18. Utility of an intraoperative ultrasound in lateral approach mini-parathyroidectomy with discordant pre-operative imaging
  19. The effects of CPAP treatment on nasal mucosa in patients with obstructive sleep apnea
  20. Preliminary results of a novel quorum sensing inhibitor against pneumococcal infection and biofilm formation with special interest to otitis media and cochlear implantation
  21. Critical literature review on the management of intraparotid facial nerve schwannoma and proposed decision-making algorithm
  22. Thyroid and parathyroid dysfunction after total laryngectomy in patients with laryngeal carcinoma
  23. Cochlear implantation in children with "CHARGE syndrome": surgical options and outcomes
  24. Lower cranial nerves function after surgical treatment of Fisch Class C and D tympanojugular paragangliomas
  25. Reversible cochleo-vestibular deficits in two cases of jugular foramen tumor after surgery
  26. Is cartilage better than temporalis muscle fascia in type I tympanoplasty? Implications for current surgical practice
  27. Age dependence of otoacoustic emissions: the loss of amplitude is primarily caused by age-related hearing loss and not by aging alone
  28. Endoluminal stenting for tracheal stenosis
  29. A study on the prognostic significance of qualitative olfactory dysfunction
  30. Endolaryngeal cordectomy using cold instruments for treatment of T1 glottic cancers
  31. Tuberculous otitis media developing as a complication of tympanostomy tube insertion
  32. Histological features and malignant transformation of inverted papilloma

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