Journal Title
Title of Journal: Springer Semin Immun
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Abbravation: Springer Seminars in Immunopathology
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Publisher
Springer-Verlag
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Authors: Christoph J Binder Gregg J Silverman
Publish Date: 2004/12/18
Volume: 26, Issue: 4, Pages: 385-404
Abstract
In recent years the subject of natural antibodies has been revisited and the immunobiological roles of these humoral factors are being better defined These antibodies are secreted by distinct sets of innatelike B cells B1 cells and marginal zone B cells which arise early in development to become the sources of “natural immune memory” Due to their interactions with a variety of selfdeterminants natural antibodies have previously been postulated to play roles in the maintenance of host homeostasis A central paradigm has recently been developed from the demonstration that oxidation derived epitopes on apoptotic cells and oxidized lowdensity lipoproteins are recognized by the phosphorylcholinespecific germline encoded B1 cell natural antibody T15 which has provided important insights into possible “housekeeping” functions under both normal and pathological conditions In this review the potential functions of natural antibodies in the pathogenesis and progression of the chronic inflammatory condition of atherosclerosis are discussed as well as their capacities for apoptotic cell binding and clearance These interactions of natural antibodies and oxidationepitopes from phospholipids appear to provide a dynamic immunobiological connection linking host responses in infection autoimmunity and atherosclerosisWe appreciate the critical reading and helpful discussion of JL Witztum We also acknowledge the continued assistance of W Palinski and the members of the Silverman and Witztum research groups This work was supported by grants AR47360 HL69464 AR50659 and HL56989 SCOR in Molecular Medicine and Atherosclerosis from NIH and the Alliance for Lupus Research CJ Binder was supported by a PhD scholarship from the Boehringer Ingelheim Fonds a scholarship from the Austrian Academy of Science and a fellowship from the American Heart Association AHA Western Affiliates
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