Modeling Lipid Membranes

Authors: Christophe Chipot Michael L Klein Mounir Tarek

Publish Date: 2005

Volume: , Issue: , Pages: 929-958

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Abstract

Membranes consist of an assembly of a wide variety of lipids 1 proteins and carbohydrates that selforganize to assume a host of biological functions in the cell machinery like the passive and active transport of matter the capture and storage of energy the control of the ionic balance or the intercellular recognition and signalling In essence membranes act as walls that delimit the interior of the cell from the outside environment preventing the free translocation of small molecules from one side to the other At an atomic level knowledge of both the structure and the dynamics of membranes remains to a large extent fragmentary on account of the remarkable fluidity of these systems under physiological conditions As a result the amount of experimental information that can be interpreted directly in terms of positions and motions is still rather limited

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