Paper Search Console

Home Search Page Alphabetical List About Contact

Journal Title

Title of Journal: Diabetologia

Search In Journal Title:

Abbravation: Diabetologia

Search In Journal Abbravation:



Search In Publisher:



Search In ISSN:
Search In Title Of Papers:

Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoimmune diabetes in the non-obese diabetic mouse

Authors: F. Calcinaro, S. Dionisi, M. Marinaro, P. Candeloro, V. Bonato, S. Marzotti, R. B. Corneli, E. Ferretti, A. Gulino, F. Grasso, C. De Simone, U. Di Mario, A. Falorni, M. Boirivant, F. Dotta,

Publish Date: 2005/06/29
Volume: 48, Issue:8, Pages: 1565-1575
PDF Link


Recent observations suggest the involvement of the gastrointestinal tract in the pathogenesis of islet autoimmunity. Thus, the modulation of gut-associated lymphoid tissue may represent a means to affect the natural history of the disease. Oral administration of probiotic bacteria can modulate local and systemic immune responses; consequently, we investigated the effects of oral administration of the probiotic compound VSL#3 on the occurrence of diabetes in non-obese diabetic (NOD) mice.VSL#3 was administered to female NOD mice three times a week starting from 4 weeks of age. A control group received PBS. Whole blood glucose was measured twice a week. IFN-γ and IL-10 production/expression was evaluated by ELISA in culture supernatants of mononuclear cells isolated from Peyer’s patches and the spleen, and by real-time PCR in the pancreas. Insulitis was characterised by immunohistochemistry and histomorphometric studies.Early oral administration of VSL#3 prevented diabetes development in NOD mice. Protected mice showed reduced insulitis and a decreased rate of beta cell destruction. Prevention was associated with an increased production of IL-10 from Peyer’s patches and the spleen and with increased IL-10 expression in the pancreas, where IL-10-positive islet-infiltrating mononuclear cells were detected. The protective effect of VSL#3 was transferable to irradiated mice receiving diabetogenic cells and splenocytes from VSL#3-treated mice.Orally administered VSL#3 prevents autoimmune diabetes and induces immunomodulation by a reduction in insulitis severity. Our results provide a sound rationale for future clinical trials of the primary prevention of type 1 diabetes by oral VSL#3 administration.



Search In Abstract Of Papers:
Other Papers In This Journal:

  1. Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoimmune diabetes in the non-obese diabetic mouse
  2. Comparison of high-fat and high-protein diets with a high-carbohydrate diet in insulin-resistant obese women
  3. Low-density-lipoprotein cholesterol concentrations and risk of incident diabetes: epidemiological and genetic insights from the Framingham Heart Study
  4. AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice
  5. Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study
  6. Angiotensin-I converting enzyme insertion/deletion polymorphism and its association with diabetic nephropathy: a meta-analysis of studies reported between 1994 and 2004 and comprising 14
  7. Microarray analysis of genes with impaired insulin regulation in the skeletal muscle of type 2 diabetic patients indicates the involvement of basic helix-loop-helix domain-containing
  8. Amino acids require glucose to enhance
  9. Retinol-binding protein 4 is associated with components of the metabolic syndrome
  10. Effects of exenatide on circulating glucose
  11. Mouse hypothalamic GT1-7 cells demonstrate AMPK-dependent intrinsic glucose-sensing behaviour
  12. Thiazolidinediones reduce the LDL binding affinity of non-human primate vascular cell proteoglycans
  13. Glucose tolerance and insulin resistance in Indian children: relationship to infant feeding pattern
  14. Environmental pollutants and type 2 diabetes: a review of mechanisms that can disrupt beta cell function
  15. The prevalence of insulin autoantibodies at the onset of Type 1 diabetes is higher in males than females during adolescence
  16. Anaemia in diabetes: is there a rationale to TREAT?
  17. Cellular mechanisms by which proinsulin C-peptide prevents insulin-induced neointima formation in human saphenous vein
  18. Potential impact of American Diabetes Association (2000) criteria for diagnosis of gestational diabetes mellitus in Spain
  19. Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice
  20. Characterisation of subjects with early abnormalities of glucose tolerance in the Stockholm Diabetes Prevention Programme: the impact of sex and type 2 diabetes heredity

Search Result:

Help video to use 'Paper Search Console'