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Title of Journal: Cell Tissue Res

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Abbravation: Cell and Tissue Research

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Changes in mammary fat pad composition and lipolytic capacity throughout pregnancy

Authors: Esperanza Pujol, Ana M. Proenza, Pilar Roca, Isabel Lladó,

Publish Date: 2005/11/22
Volume: 323, Issue:3, Pages: 505-511
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Changes in rat mammary fat pad during pregnancy were assessed by studying differences in the morphology and composition of the pad and in the levels of proteins involved in the accumulation and mobilization of fat stores. During pregnancy, the mammary fat pad weight had increased 1.8-fold by day 20, as compared with control rats. DNA content had increased two-fold by day 13 and remained stable until day 20. Protein content showed a two-fold increase on day 20, compared with control rats. As pregnancy advanced, both the percentage of mammary gland cells with respect to the whole mammary fat pad and the size of the adipocytes increased. The specific content of the different elements of the lipolytic pathway, viz. (α2A-adrenergic receptor (AR), β3-AR, cAMP-dependent protein kinase and hormone-sensitive lipase (HSL)) underwent a decrease as pregnancy progressed, although adenylate cyclase increased greatly. The lipoprotein lipase (LPL) content per gram of tissue increased with pregnancy and the HSL-to-LPL ratio reflected a continuous increase in the triglyceride storage throughout pregnancy. Thus, the mammary fat pad undergoes extensive morphological, compositional and metabolic transformation during pregnancy, attributable to the development of the mammary gland. The various elements of the lipolytic pathway and LPL undergo major changes during the development of the mammary gland focused towards the increase of fat stores and allowing the accumulation of lipid droplets in the epithelial mammary cells and an increase in adipocyte size.This investigation was supported by the Fondo de Investigaciones Sanitarias (PI021339) of the Spanish Government and by the Conselleria d'Innovació i Energia de la Comunitat Autònoma de les Illes Balears (PRDIB–2002GC4–24). E.P. was supported by a grant from the Spanish Government.The authors are grateful to Dr. J. Oliver for his help with the preparation of the histological samples and for his useful advice regarding the measurement of the morphometric parameters. We also thank Ms. M. Pocoví for her technical assistance on the preparation of the histological sections.



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Other Papers In This Journal:

  1. Changes in mammary fat pad composition and lipolytic capacity throughout pregnancy
  2. Neuroimmunomodulation in human autoimmune liver disease
  3. Transcription factor PEX1 modulates extracellular matrix turnover through regulation of MMP-9 expression
  4. Fusion failure of dense-cored proacrosomal vesicles in an inducible mouse model of male infertility
  5. The roles of tumor- and metastasis-promoting carcinoma-associated fibroblasts in human carcinomas
  6. Segregation of neuronal and neuroendocrine differentiation in the sympathoadrenal lineage
  7. The TIM23 mitochondrial protein import complex: function and dysfunction
  8. The effect of the transplanted pineal gland on the sympathetic innervation of the rat sublingual gland
  9. Transcription factor Yin-Yang 2 alters neuronal outgrowth in vitro
  10. Lack of TrkB and TrkC signaling alters the synaptogenesis and maturation of mossy fiber terminals in the hippocampus
  11. Immunohistochemical distribution of proteins belonging to the receptor-mediated and the mitochondrial apoptotic pathways in human placenta during gestation
  12. Differential expression of the bone and the liver tissue non-specific alkaline phosphatase isoforms in brain tissues
  13. Thymic alterations in mice deficient for the SNARE protein VAMP8/endobrevin
  14. Tenogenic differentiation of equine adipose-tissue-derived stem cells under the influence of tensile strain
  15. Agrin becomes concentrated at neuroeffector junctions in developing rodent urinary bladder
  16. Cultured gastrointestinal smooth muscle cells: cell response to contractile agonists depends on their phenotypic state
  17. Impact of extracellular RNA on endothelial barrier function
  18. Characterization of miRNA processing machinery in the embryonic chick lung

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