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Publisher
Springer, London
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Authors: Silvia S Pierangeli Azzudin E Gharavi
Publish Date: 2006
Volume: , Issue: , Pages: 532-543
Abstract
Our observations and those from others give further support to our hypothesis that “autoimmune aPL” may be generated by immunization with products from bacteria or viruses after incidental exposure or infection We also were able to generate APSlike syndrome in a strain of mice susceptible to autoimmunity indicating that other factors are likely to be involved such as genetic predisposition Furthermore not all aPL generated were pathogenic Based on the clinical experience and on the numerous reports indicating presence of aPL in large number of infectious diseases it may be expected that not all aPL produced during infection will be pathogenic A limited number aPL induced by certain viral/bacterial products would be pathogenic in certain genetically predisposed individuals Further studies to identify the agents responsible for induction the pathogenic aPL are needed Identification of those bacterial and/or viral agents may help finding strategies for the prevention of production of aPL “pathogenic” antibodies Alternatively free peptides may be used to induce tolerance against aPL production or to abrogate their pathogenic effects
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