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Title of Journal: Mol Cell Biochem

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Abbravation: Molecular and Cellular Biochemistry

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Kluwer Academic Publishers-Plenum Publishers

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DOI

10.1002/andp.19384230401

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ISSN

1573-4919

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Hepatitis B virus replication causes oxidative stress in HepAD38 liver cells

Authors: Tamara Severi, Chunxiao Ying, Joris Robert Vermeesch, David Cassiman, Lieselotte Cnops, Chris Verslype, Johan Fevery, Lutgarde Arckens, Johan Neyts, Jos F. van Pelt,

Publish Date: 2006/09/08
Volume: 290, Issue:1-2, Pages: 79-85
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Abstract

We used human hepatoma HepAD38 cells, in which HBV production is under the control of a tetracycline-regulated promotor, to investigate changes induced in the host cell by HBV replication that could contribute to malignant transformation. Parameters of oxidative stress (malondialdehyde, glutathione) and cell proliferation were determined at different times after induction (0–96 h). In HBV-producing cells, the redox status peaked at 72 h. cDNA micro array analysis at 72 h post induction revealed 3 groups of genes that were up-regulated by HBV: (i) heat shock proteins, (ii) oxidative and metabolic stress and (iii) growth and apoptosis related genes. Continuous HBV production did not accelerate karyotypic changes in cells cultured for 4 months (18 passages). In conclusion: HBV replication modulates host gene expression and induces oxidative stress. In this HepAD38 model early events (0–4 days) in the host cell after induction of HBV replication can be studied under strictly defined conditions.


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Other Papers In This Journal:

  1. Hepatitis B virus replication causes oxidative stress in HepAD38 liver cells
  2. Retinol-binding protein 4 as a risk factor for cholesterol gallstone formation
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  4. Pre-clinical characterization of CX-4945
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  6. The synergistic induction of cyclooxygenase-2 in lung fibroblasts by angiotensin II and pro-inflammatory cytokines
  7. Fatty acylation enhances cellular localization of dansylated phenylalanines
  8. Tetramerization of SATB1 is essential for regulating of gene expression
  9. The molecular interaction of a copper chelate with human P-glycoprotein
  10. Increased antitumor capability of fiber-modified adenoviral vector armed with TRAIL against bladder cancers
  11. Hormonal imbalance and disturbances in carbohydrate metabolism associated with chronic feeding of high sucrose low magnesium diet in weanling male wistar rats
  12. Silencing SATB1 inhibits proliferation of human osteosarcoma U2OS cells
  13. Characterization of a multidrug-resistant chronic myeloid leukemia cell line presenting multiple resistance mechanisms
  14. Increased synthesis of folate transporters regulates folate transport in conditions of ethanol exposure and folate deficiency
  15. Inhibitory effect of anti-aminopeptidase N/CD13 antibodies on fibroblast migration
  16. Knockdown of ZNF403 inhibits cell proliferation and induces G2/M arrest by modulating cell-cycle mediators
  17. Induction of Fas-mediated extrinsic apoptosis
  18. Expression and analysis of two novel rat organic cation transporter homologs

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