Authors: Necip Ilhan Dilara Seckin Nevin Ilhan Yilmaz Ozbay
Publish Date: 2006/12/09
Volume: 23, Issue: 3, Pages: 205-211
Abstract
We measured plasma levels of ADMA nitrate + nitrite NOx total homocysteine tHCY and renal function in 106 people with angiographic evidence of coronary artery disease CAD including 46 with single vessel disease and 60 with double/triple vessel disease and in 70 agematched individuals without any angiography evidence of CAD Also the levels of these parameters were evaluated according to their history of MI Plasma tHcy and ADMA were measured by HPLC and the levels of NOx using the Griess reactionLevels of ADMA ACE and tHcy levels were significantly higher and NO level was significantly lower in CAD patients compared with controls but there were no significant differences among patients with or without history of MI and between patients with single compared to those with double/triple vessel disease Additionally a negative correlation was found between ADMANOx r = −0396 p = 0001 and between tHcyNOx r = −0262 p = 0027 In the entire study group ADMA level was significantly higher in patients with creatinine clearance CrCl 91 mL/min than in patients with CrCl ≥ 91 mL/min 060 ± 023 micromoles/L versus 049 ± 025 micromoles/L p = 005
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