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Title of Journal: Eur J Pediatr

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Abbravation: European Journal of Pediatrics

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Springer-Verlag

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10.1007/bf02057779

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1432-1076

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Transient antiphospholipid antibodies associated with acute infections in children: a report of three cases and a review of the literature

Authors: H. Mizumoto, T. Maihara, E. Hiejima, M. Shiota, A. Hata, S. Seto, T. Atsumi, T. Koike, D. Hata,

Publish Date: 2006/03/22
Volume: 165, Issue:7, Pages: 484-488
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Abstract

We describe two previously healthy children who had multiple ecchymoses several days after acute infection. In both cases, the prothrombin time (PT) and the activated partial thromboplastin time (APTT) were prolonged. Further examinations revealed the presence of lupus anticoagulant (LA), phosphatidylserine-dependent antiprothrombin antibodies (aPS/PT), and low serum complement. In both cases, we confirmed the presence of a serum immune complex. The patients’ symptoms improved spontaneously within 1 week, and all laboratory data normalized within several months. We also describe another asymptomatic case positive for LA and aPS/PT presumably associated with cytomegalovirus infection. The prevalence of transient antiphospholipid antibodies associated with viral infections in children must be much higher than we expected. We have to take it into consideration when we see abnormal coagulation results, but the occurrence of significant bleeding symptoms is rare.


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Other Papers In This Journal:

  1. Massive gastrointestinal haemorrhage in isolated intestinal Henoch-Schonlein purpura with response to intravenous immunoglobulin infusion
  2. Reversible posterior encephalopathy syndrome associated with micronodular adrenocortical disease and Cushing syndrome
  3. Auto-immune pancytopenia in a child with DiGeorge syndrome
  4. Effective parenteral clodronate treatment of a child with severe juvenile idiopathic osteoporosis
  5. Evaluation of the Omron MX3 Plus monitor for blood pressure measurement in adolescents
  6. Paroxetine during breast-feeding: infant weight gain and maternal adherence to counsel
  7. Characteristics of the menstrual cycle in 13-year-old Flemish girls and the impact of menstrual symptoms on social life
  8. Proportional assist versus assist control ventilation in premature infants
  9. Thrombus obstructing the right ventricle outflow tract in a neonate with methylenetetrahydrofolate reductase 677TT genotype
  10. Eosinophilic tubulointerstitial nephritis on treatment with isotretinoin
  11. A European Society of Paediatric and Neonatal Intensive Care (ESPNIC) survey of European critical care management of young people
  12. Clinical practice
  13. Parameters affecting length of stay in a pediatric emergency department: a retrospective observational study
  14. Clustering of (auto)immune diseases with early-onset and complicated inflammatory bowel disease
  15. Risk factors for ventilator-associated pneumonia in the neonatal intensive care unit: a meta-analysis of observational studies
  16. Onset of acquired autoimmune hypothyroidism in infancy: a presentation of delayed gross-motor development and rhabdomyolysis
  17. Unusual clinical presentation of primary hypothyroidism in a very young infant caused by autoimmune thyroiditis: case report and update of the literature
  18. A quality improvement initiative to reduce central line infection in neonates using checklists
  19. Cognition and the risk of eating disorders in Spanish adolescents: the AVENA and AFINOS studies
  20. Transient antiphospholipid antibodies associated with acute infections in children: a report of three cases and a review of the literature
  21. Eosinophilic tubulointerstitial nephritis on treatment with isotretinoin

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