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Title of Journal: Ann Hematol

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Abbravation: Annals of Hematology

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In vitro cross-resistance to nucleoside analogues and inhibitors of topoisomerase 1 and 2 in acute myeloid leukemia

Authors: Michael Fiegl, Inka Zimmermann, Isolde Lorenz, Wolfgang Hiddemann, Jan Braess,

Publish Date: 2007/08/21
Volume: 87, Issue:1, Pages: 27-33
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Only about one third of all patients with acute myeloid leukemia (AML) will be cured by common chemotherapy regimens. Susceptibility towards chemotherapy either of the leukemic bulk or the leukemic stem cell is considered the major determining parameter for long-term outcome. The purpose of the present study was to investigate whether chemoresistance was correlated between different antileukemic drugs or not. We determined the lethal concentration of chemotherapy necessary to reduce viability of cells to 50% compared to untreated control (LC50) as a surrogate marker of chemotherapy susceptibility of six established chemotherapeutic agents [cytarabine (median 0.83 μg/ml), daunorubicine (0.09 μg/ml), idarubicine (0.03 μg/ml), mitoxantrone (0.05 μg/ml), etoposide (4.81 μg/ml), and topotecan (0.14 μg/ml)] in an overall number of 147 samples from consecutive patients with AML by WST-1 assay in vitro. We found that susceptibility to chemotherapy was significantly correlated between all six agents (all p values 



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Other Papers In This Journal:

  1. In vitro cross-resistance to nucleoside analogues and inhibitors of topoisomerase 1 and 2 in acute myeloid leukemia
  2. Prophylactic intravenous immunoglobulin during autologous haemopoietic stem cell transplantation for multiple myeloma is not associated with reduced infectious complications
  3. Risk factors for poor treatment outcome and central nervous system relapse in diffuse large B-cell lymphoma with bone marrow involvement
  4. A systematic review and meta-analysis of rituximab-based immunochemotherapy for subtypes of diffuse large B cell lymphoma
  5. Therapeutic implication of BAL in patients with neutropenia
  6. Effect of altered iron metabolism on markers of haem biosynthesis and intestinal iron absorption in mice
  7. Glucose-6-phosphate dehydrogenase deficiency and risk of diabetes: a systematic review and meta-analysis
  8. Epidemiological profile of hemoglobinopathies in the Mauritanian population
  9. Haemoglobin Hokusetsu [�52 (D3)] Asp?Gly in German families associated with inclusion body
  10. Suggestion of response evaluation criteria in patients with ocular adnexal mucosa-associated lymphoid tissue lymphoma (OAML)
  11. Porcine antilymphocyte globulin (p-ALG) plus cyclosporine A (CsA) treatment in acquired severe aplastic anemia: a retrospective multicenter analysis
  12. Is the quantity of circulatory cell-free DNA in human plasma and serum samples associated with gender
  13. Reusable terminal tap water filters for nosocomial legionellosis prevention
  14. Association between low uric acid levels and acute graft-versus-host disease
  15. Treatment with monoclonal antibodies in acute lymphoblastic leukemia: current knowledge and future prospects
  16. Telomere elongation and clinical response to androgen treatment in a patient with aplastic anemia and a heterozygous hTERT gene mutation
  17. High-risk AML complicated by pulmonary aspergillosis: successful treatment with nonmyeloablative stem cell transplantation and long-term administration of voriconazole
  18. Perioperative management of a patient with Fechtner syndrome
  19. Hemophagocytosis associated with leukemia: a striking association with juvenile myelomonocytic leukemia
  20. Storage time of red blood cell concentrates and adverse outcomes after cardiac surgery: a cohort study

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