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Title of Journal: J Thromb Thrombolysis

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Abbravation: Journal of Thrombosis and Thrombolysis

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Springer US

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DOI

10.1007/bf00498416

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1573-742X

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New oral Xa and IIa inhibitors updates on clinica

Authors: Sylvia Haas
Publish Date: 2007/10/27
Volume: 25, Issue: 1, Pages: 52-60
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Abstract

Heparins and VKAs have been the cornerstones of anticoagulation therapy for several decades and these agents have become most important drugs in the primary and secondary prevention of venous and arterial thromboembolic disease Although effective their use has been hampered by numerous limitations In the search for new agents matching the ‘ideal’ anticoagulant profile a number of different steps in the coagulation cascade have been targeted including direct thrombin inhibition and direct inhibition of Factor Xa There are currently a host of promising new agents at various stages of development and clinical evaluation With potential benefits including predictable efficacy rapid onset of action ability to bind clotbound coagulation factors and no requirement for therapeutic monitoring these new agents are set to improve the management of thromboembolic disorders

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  2. Comparison of platelet inhibition by prasugrel versus ticagrelor over time in patients with acute myocardial infarction
  3. Does supervised exercise after deep venous thrombosis improve recanalization of occluded vein segments? A randomized study
  4. Anticoagulation in the management of venous thromboembolism in the cancer patient
  5. Association between sleep condition and arterial stiffness in Chinese adult with nonalcoholic fatty liver disease
  6. In vitro shear stress modulates antithrombogenic potentials of human endothelial progenitor cells
  7. Polymorphism in the methylenetetrahydrofolate reductase (C677T) gene and homocysteine levels: a comparison in Brazilian patients with coronary arterial disease, ischemic stroke and peripheral arterial obstructive disease
  8. Role of thrombophilia testing: con
  9. Venous thromboembolism and cancer: a systematic review
  10. Dabigatran-associated subdural hemorrhage: using thromboelastography (TEG ® ) to guide decision-making
  11. Proceedings of the 10th National Conference on Anticoagulant Therapy
  12. Comparative efficacy of in vitro and in vivo metabolized aspirin in the DeBakey ventricular assist device
  13. The relationship between gender and age with monocyte tissue factor expression
  14. Determination of rivaroxaban by different factor Xa specific chromogenic substrate assays: reduction of interassay variability
  15. A comparison of direct thrombin inhibitors in the treatment of heparin-induced thrombocytopenia: a single institution experience
  16. US Food and Drug Administration approval of generic versions of complex biologics: implications for the practicing physician using low molecular weight heparins
  17. Measurement of dabigatran and rivaroxaban in primary prevention of venous thromboembolism in 106 patients, who have undergone major orthopedic surgery: an observational study
  18. Abnormal asymmetric dimethylarginine/nitric oxide balance in patients with documented coronary artery disease: relation to renal function and homocysteine
  19. Tailoring clopidogrel dose according to multiple electrode aggregometry decreases the rate of ischemic complications after percutaneous coronary intervention
  20. Cardiovascular risk factors and outcome in patients with retinal vein occlusion
  21. Impact of type of thrombolytic agent on in-hospital outcomes in ST-segment elevation myocardial infarction patients in the Middle East
  22. Prognostic significance of multidetector computed tomography in normotensive patients with pulmonary embolism: rationale, methodology and reproducibility for the PROTECT study
  23. Increased platelet activation in patients with slow coronary flow
  24. Biomarkers of deep venous thrombosis
  25. Thromboembolic complications following a first isolated episode of superficial vein thrombosis: a cross-sectional retrospective study
  26. The impact of factor Xa inhibition on axial dependent arterial thrombus formation triggered by a tissue factor rich surface
  27. Spontaneous coronary thrombosis following thrombolytic therapy for acute cardiovascular accident and stroke: a case study
  28. Anti-coagulant activity of a metalloprotease: further characterization from the Indian cobra ( Naja naja ) venom
  29. Evaluation of the Alere D-dimer test for point of care testing
  30. Strategies and outcomes of periprocedural bridging therapy with low-molecular-weight heparin in patients with mechanical heart valves
  31. Elevated concentration of placental growth factor (PlGF) and long term risk in patients with acute coronary syndrome in the PROVE IT-TIMI 22 trial
  32. Association between micro particle-tissue factor activity, factor VIII activity and recurrent VTE in patients with acute pulmonary embolism
  33. Methylenetetrahydrofolate reductase (MTHFR) C677T genetic polymorphism and late infarct-related coronary artery patency after thrombolysis
  34. Are surgical patients at risk of venous thromboembolism currently meeting the Surgical Care Improvement Project performance measure for appropriate and timely prophylaxis?
  35. Evaluation of von Willebrand factor and ADAMTS-13 antigen and activity levels in sickle cell disease patients in Kuwait
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