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Title of Journal: J Thromb Thrombolysis

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Abbravation: Journal of Thrombosis and Thrombolysis

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Springer US

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DOI

10.1016/0190-9622(91)70163-V

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1573-742X

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Polymorphism in the methylenetetrahydrofolate redu

Authors: Adriano Sabino Ana Paula Fernandes Luciana Moreira Lima Daniel Dias Ribeiro Marinez Oliveira Sousa Maria Elizabeth Rennó de Castro Santos Ana Paula Lucas Mota Luci Maria Sant’Ana Dusse Maria das Graças Carvalho
Publish Date: 2007/11/27
Volume: 27, Issue: 1, Pages: 82-
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Abstract

This study aimed to compare plasma levels of total homocysteine tHcy in different arterial events as well as to investigate an association between homocysteine levels and C677T polymorphism in Brazilian patients A total of 145 subjects were enrolled in this study including 43 patients with coronary arterial disease CAD 21 with ischemic stroke IS 44 with peripheral arterial obstructive disease PAOD and 37 control subjects A preliminary analysis showed significant difference for tHcy plasma levels between patients with CAD P = 0003 or PAOD P = 003 compared to controls However after adjustment for sex age total cholesterol LDL diabetes tabagism or C677T polymorphism no significant differences were detected in tHcy levels among patients groups and controls No significant correlation was demonstrated for C677T polymorphism and homocysteine levels These results indicate that increased Hcy levels may not be considered an independent risk factor for atherothrombotic diseases in Brazilian patients

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