EEG and fMRI Coregistration to Investigate the Cor

Authors: Emanuela Formaggio Silvia Francesca Storti Mirko Avesani Roberto Cerini Franco Milanese Anna Gasparini Michele Acler Roberto Pozzi Mucelli Antonio Fiaschi Paolo Manganotti

Publish Date: 2008/07/22

Volume: 21, Issue: 2, Pages: 100-111

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Abstract

Electroencephalography combined with functional magnetic resonance imaging EEGfMRI may be used to identify blood oxygenation level dependent BOLD signal changes associated with physiological and pathological EEG event In this study we used EEGfMRI to determine the possible correlation between topographical movementrelated EEG changes in brain oscillatory activity recorded from EEG electrodes over the scalp and fMRIBOLD cortical responses in motor areas during finger movement Thirtytwo channels of EEG were recorded in 9 subjects during eyesopen condition inside a 15 T magnetic resonance MR scanner using a MRcompatible EEG recording system Offline MRI artifact subtraction software was applied to obtain continuous EEG data during␣fMRI acquisition For EEG data analysis we used the eventrelatedsynchronization/desynchronization ERS/ERD approach to investigate where movementrelated decreases in alpha and beta power are located For image statistical analysis we used a general linear model GLM approach There was a significant correlation between the positivenegative ratio of BOLD signal peaks and ERD values in the electrodes over the region of activation We conclude that combined EEGfMRI may be used to investigate movementrelated oscillations of the human brain inside an MRI scanner and the movementrelated changes in the EMG or EEG signals are useful to identify the brain activation sources responsible for BOLDsignal changes

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