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Title of Journal: J Gastrointest Surg

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Abbravation: Journal of Gastrointestinal Surgery

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Small Intestinal Submucosa as a Bioscaffold for Tissue Regeneration in Defects of the Colonic Wall

Authors: Jens Hoeppner, Vladan Crnogorac, Goran Marjanovic, Eva Jüttner, Wojciech Karcz, Hans-Fred Weiser, Ullrich Theodor Hopt,

Publish Date: 2008/09/03
Volume: 13, Issue:1, Pages: 113-119
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Small intestinal submucosa (SIS) has proved considerable regenerative capacity for repair of bowel wall defects at different locations. This study assesses the effectiveness of SIS in the repair of defects at a gastrointestinal location with strong bacterial contamination.Fourteen domestic pigs had a 4.5 × 1.5 cm full-thickness defect created on the wall of the descending colon. Repair was done by suturing an SIS patch to the defect. Grafts were harvested after 30, 60, and 90 days. Outcomes were evaluated on the basis of animal survival, clinical course, and macroscopic, histological, and immunohistochemical assessment.All animals survived the scheduled observation period. No patch failure and no postoperative leakage occurred. No luminal narrowing occurred at SIS-patched colon. Morphometric examination revealed contraction of the patched area of 77% after 30 days and more than 90% after 60 and 90 days. By 60 and 90 days, all animals showed mucosal regeneration at the margins of the graft. By 90 days, regeneration of smooth muscle cells was present at the original site of the muscularis mucosae. None of the reconstructed areas showed complete mucosal coverage or regeneration of a structured muscular layer.SIS can be used effectively for patch repair of colonic defects in a porcine model. Distinctive contraction of the reconstructed area and limited architectural regeneration of the bowel wall suggest limitation of morphologic regenerative capacities in large-bowel regeneration.



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Other Papers In This Journal:

  1. Is there a Role for Surgery with Adequate Nodal Evaluation Alone in Gastric Adenocarcinoma?
  2. Outcomes Improvement Is Not Continuous Along the Learning Curve for Pancreaticoduodenectomy at the Hospital Level
  3. Small Intestinal Submucosa as a Bioscaffold for Tissue Regeneration in Defects of the Colonic Wall
  4. Prognostic Factors and 10-Year Survival in Patients with Hepatocellular Carcinoma After Curative Hepatectomy
  5. Reduction of the Incidence of Delayed Gastric Emptying in Side-to-Side Gastrojejunostomy in Subtotal Stomach-Preserving Pancreaticoduodenectomy
  6. Surgeon Volume is Predictive of 5-Year Survival in Patients with Hepatocellular Carcinoma after Resection: A Population-Based Study
  7. Superior Mesenteric Artery Syndrome: Diagnosis and Treatment Strategies
  8. Choledochal Cysts: Differences Between Pediatric and Adult Patients
  9. Metastatic Melanoma Causing Jejunal Intussusception
  10. Giant Splenic Artery Pseudoaneurysm
  11. Impact of Resection for Primary Colorectal Cancer on Outcomes in Patients with Synchronous Colorectal Liver Metastases
  12. How I Do It: Laparoscopic Paraesophageal Hernia Repair
  13. Clinicopathologic Features of Gastric Carcinoma with Signet Ring Cell Histology
  14. High-Resolution Manometry Classifications for Idiopathic Achalasia in Patients with Chagas' Disease Esophagopathy
  15. Transnasal Fine Gastrointestinal Fiberscope-guided Long Tube Insertion for Patients with Small Bowel Obstruction
  16. Pancreaticogastrostomy Versus Pancreaticojejunostomy After Pancreaticoduodenectomy: a Systematic Review and Meta-Analysis of Randomized Controlled Trials
  17. Extracorporeal Hypothermic Perfusion Device for Intestinal Graft Preservation to Decrease Ischemic Injury During Transportation
  18. A Nationwide Analysis of Changes in Severity and Outcomes of Inflammatory Bowel Disease Hospitalizations
  19. Perioperative Complications After Neoadjuvant Chemotherapy With and Without Bevacizumab for Colorectal Liver Metastases
  20. Pharmacological management to prevent ileus in major abdominal surgery: a systematic review and meta-analysis

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