Journal Title
Title of Journal: Front Chem Eng China
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Abbravation: Frontiers of Chemical Engineering in China
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Publisher
SP Higher Education Press
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Authors: Xia Wang Hui Chen Yanni Guo Yuzhong Su Hongtao Wang Jun Li
Publish Date: 2008/09/27
Volume: 2, Issue: 4, Pages: 361-367
Abstract
Using the CO2and N2assisted atomization processes the production of ibuprofen/lipid composite microparticles is investigated in which the lipid includes myristic acid and tripalmitin The produced composite particles show similar morphology to that of the purelipids obtained by the same process In the case of the N2assisted process the average size of composite particles is slightly larger than that of the pure lipid particles due to the difficulty of solidification when using N2 In the case of the CO2assisted process the average size of composite particles is slightly smaller than that of the pure myristic acid particles but slightly larger than that of the pure tripalmitin particles The dissolution study reveals that the drug release from the ibuprofen/myristic acid particles is enhanced in comparison with that of the unprocessed ibuprofen For the particles produced by the N2assisted process the Xray diffraction XRD patterns clearly indicate the encapsulation of ibuprofen into myristic acid The obtained ibuprofen/tripalmitin composite particles with 5 or 20 of ibuprofen in mass evidently show the controlled drug release only about 20 of the drug is released in 500 min from the ibuprofen/tripalmitin composite particles consisting of 20 ibuprofen prepared by the CO2assisted process and the same release is obtained from the ibuprofen/tripalmitin composite particles containing 5 ibuprofen prepared by the N2assisted process
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