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Abbravation: Psychopharmacology

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Reinforcing and subjective effects of methylphenidate in adults with and without attention deficit hyperactivity disorder (ADHD)

Authors: Scott H. Kollins, Joseph English, Rachel Robinson, Matt Hallyburton, Allan K. Chrisman,

Publish Date: 2008/12/23
Volume: 204, Issue:1, Pages: 73-
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Following screening, 33 adults (n = 16 with ADHD; n = 17 free from psychiatric diagnoses) completed four pairs of experimental sessions, each of which included a sampling session and a self-administration session. During sampling sessions, subjects received in randomized order 0 (placebo), 20, 40, and 60 mg MPH. During self-administration sessions, subjects completed a progressive ratio (PR) task to earn portions of the dose received on the corresponding sampling session. Subjective effects were recorded throughout all sessions. The main outcome measure for the study was the number of ratios completed on the PR task. Secondary measures included peak subjective effects and area-under-the-curve values for subjective effects.Compared to the control group, the ADHD group completed more ratios on the PR task. Both groups showed robust effects of methylphenidate on subjective endpoints. Main effects of group were noted on subjective effects involving concentration and arousal.



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  1. Lithium
  2. MDMA alters emotional processing and facilitates positive social interaction
  3. Arcaine and MK-801 make recall state-dependent in rats
  4. Roles of D1-like dopamine receptors in the nucleus accumbens and dorsolateral striatum in conditioned avoidance responses
  5. Haloperidol and Risperidone at high concentrations activate an in vitro inflammatory response of RAW 264.7 macrophage cells by induction of apoptosis and modification of cytokine levels
  6. Efficacy and safety of quetiapine extended release monotherapy in bipolar depression: a multi-center
  7. Monoamine transporter gene polymorphisms affect susceptibility to depression and predict antidepressant response
  8. Antipsychotic inductors of brain hypothermia and torpor-like states: perspectives of application
  9. The role of dorsal vs ventral striatal pathways in cocaine-seeking behavior after prolonged abstinence in rats
  10. Euphoriant effects of nicotine in smokers: fact or artifact?
  11. An evaluation of the serotonin system and perseverative
  12. The effect of VMAT2 inhibitor GZ-793A on the reinstatement of methamphetamine-seeking in rats
  13. The effect of VMAT2 inhibitor GZ-793A on the reinstatement of methamphetamine-seeking in rats
  14. Nicotine derived from the electronic cigarette improves time-based prospective memory in abstinent smokers
  15. Dissociable effects of noradrenaline
  16. Varenicline
  17. Efficacy of a glycine transporter 1 inhibitor TASP0315003 in animal models of cognitive dysfunction and negative symptoms of schizophrenia
  18. Positive parenting during childhood moderates the impact of recent negative events on cortisol activity in parentally bereaved youth
  19. Corticosteroid-serotonin interactions in depression: a review of the human evidence
  20. Post-extinction fluoxetine treatment prevents stress-induced reemergence of extinguished fear
  21. Social defeat increases alcohol preference of C57BL/10 strain mice; effect prevented by a CCKB antagonist
  22. Acute administration of lithium
  23. Association of time-dependent changes in mu opioid receptor mRNA
  24. Selective phosphodiesterase inhibitors: a promising target for cognition enhancement
  25. Medications influencing central cholinergic neurotransmission affect saccadic and smooth pursuit eye movements in healthy young adults
  26. Methylphenidate increases cigarette smoking in participants with ADHD
  27. Hormonal
  28. Oral cortisol impairs implicit sequence learning
  29. Influence of nicotine on positive affect in anhedonic smokers

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