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Authors: Halim Charbel James H Lewis
Publish Date: 2009
Volume: , Issue: , Pages: 307-336
Abstract
•Patients at risk for hepatitis B reactivation are those with hematological or oncological malignancies who require chemotherapy patients with nonmalignant diseases who require immunosuppression and patients with rheumatologic diseases or inflammatory bowel diseases treated with biologic response modifiers•With the administration of cytotoxic or immunosuppressive agents the immune response is suppressed viral replication is enhanced and widespread infection of hepatocytes ensues With the discontinuation of the cytotoxic or immunosuppressive therapy the immune function is restored This immune reconstitution results in a rapid destruction of hepatocytes infected with hepatitis B•Patients who are negative for HBsAg but have evidence of either circulating or intrahepatic hepatitis B viral HBV DNA are denoted as having occult HBV It is well established that chemotherapy can cause HBV reactivation even in HBsAgnegative patients with occult HBV infection
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