Authors: Turgay Celik U Cagdas Yuksel Baris Bugan Atila Iyisoy Murat Celik Sait Demirkol Halil Yaman Hurkan Kursaklioglu Selim Kilic Ersoy Isik
Publish Date: 2009/06/04
Volume: 29, Issue: 3, Pages: 310-315
Abstract
We tested the hypothesis that increased platelet activation may be present in patients with slow coronary flow SCF and may contribute to the pathogenesis of slow coronary flow phenomenon SCFP Fifty patients angiographically proven normal coronary flow control group mean age = 613 ± 70 years 43 male and 50 patients with angiographically proven SCF in all coronary arteries patient group man age = 627 ± 67 years 38 male were included in the present study Coronary flow rates of all subjects were documented by Thrombolysis In Myocardial Infarction frame count TIMI frame count Patients with a corrected TIMI frame count greater than two standard deviations from normal published range for the particular vessel were considered as having SCF Complete blood count and mean platelet volume MPV was measured from whole blood sample with Abbott CellDyne 4000 cell counter Plasma sPselectin concentrations were analyzed with sPSelectin ELISA kit There were no statistically significant differences between the two groups with respect to baseline demographic clinical and lipid parameters Not only MPV values but also plasma sPselectin levels were significantly higher in patients with the patients with SCF compared to those of controls for MPV 82 ± 07 vs 72 ± 06 fl P 0001 for sPSelectin 15 ± 03 vs 10 ± 02 ng/ml P 0001 Interestingly significant positive correlations were detected between mean TIMI frame counts and MPV and sPselectin levels for MPV r = 056 P 0001 for sPselectin r = 067 P 0001 The current study demonstrates that platelet activity is increased in the patients with SCF compared to that of the patients with normal coronary flow
Keywords: