Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: J Thromb Thrombolysis

Search In Journal Title:

Abbravation: Journal of Thrombosis and Thrombolysis

Search In Journal Abbravation:

Publisher

Springer US

Search In Publisher:

DOI

10.1007/bf03060095

Search In DOI:

ISSN

1573-742X

Search In ISSN:
Search In Title Of Papers:

Anticoagulant activity of a metalloprotease furt

Authors: M S Kumar V R Devaraj B S Vishwanath K Kemparaju
Publish Date: 2009/07/23
Volume: 29, Issue: 3, Pages: 340-348
PDF Link

Abstract

A high molecular mass non toxic metalloprotease the NNPF3 with the bound Ca2+ and Zn2+ from the Naja naja venom has been studied further for its anticoagulant property The molecular mass by MALDITOF mass spectrometry was 6781 kDa The NNPF3 exhibited fibrinogenolytic activity In addition to fibrinogen NNPF3 hydrolyzed blood and plasma clot with the later hydrolyzed about one fold higher The α polymer of fibrin was preferentially hydrolyzed over the α chain but the β chain and γ–γ dimer remained untouched It was devoid of plasminogen activation property It prolonged the activated partial thromboplastin time prothrombin time and the thrombin clotting time of citrated human plasma It did not affect the thrombin activity In mice defibrinogentaion prolonged bleeding time P  001 and reduced fibrinogen level were observed following intravenous injection Human plasma or α2macroglobulin did not but the polyvalent antivenom inhibited the NNPF3 activity In contrast to most snake venom metalloproteases it did not degrade extra cellular matrix proteins

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. The inhibition in tumor necrosis factor-α-induced attenuation in endothelial thrombomodulin expression by carvedilol is mediated by nuclear factor-κB and reactive oxygen species
  2. Comparison of platelet inhibition by prasugrel versus ticagrelor over time in patients with acute myocardial infarction
  3. Does supervised exercise after deep venous thrombosis improve recanalization of occluded vein segments? A randomized study
  4. Anticoagulation in the management of venous thromboembolism in the cancer patient
  5. Association between sleep condition and arterial stiffness in Chinese adult with nonalcoholic fatty liver disease
  6. In vitro shear stress modulates antithrombogenic potentials of human endothelial progenitor cells
  7. Polymorphism in the methylenetetrahydrofolate reductase (C677T) gene and homocysteine levels: a comparison in Brazilian patients with coronary arterial disease, ischemic stroke and peripheral arterial obstructive disease
  8. Role of thrombophilia testing: con
  9. Venous thromboembolism and cancer: a systematic review
  10. Dabigatran-associated subdural hemorrhage: using thromboelastography (TEG ® ) to guide decision-making
  11. Proceedings of the 10th National Conference on Anticoagulant Therapy
  12. Comparative efficacy of in vitro and in vivo metabolized aspirin in the DeBakey ventricular assist device
  13. The relationship between gender and age with monocyte tissue factor expression
  14. Determination of rivaroxaban by different factor Xa specific chromogenic substrate assays: reduction of interassay variability
  15. A comparison of direct thrombin inhibitors in the treatment of heparin-induced thrombocytopenia: a single institution experience
  16. US Food and Drug Administration approval of generic versions of complex biologics: implications for the practicing physician using low molecular weight heparins
  17. Measurement of dabigatran and rivaroxaban in primary prevention of venous thromboembolism in 106 patients, who have undergone major orthopedic surgery: an observational study
  18. Abnormal asymmetric dimethylarginine/nitric oxide balance in patients with documented coronary artery disease: relation to renal function and homocysteine
  19. Tailoring clopidogrel dose according to multiple electrode aggregometry decreases the rate of ischemic complications after percutaneous coronary intervention
  20. Cardiovascular risk factors and outcome in patients with retinal vein occlusion
  21. Impact of type of thrombolytic agent on in-hospital outcomes in ST-segment elevation myocardial infarction patients in the Middle East
  22. Prognostic significance of multidetector computed tomography in normotensive patients with pulmonary embolism: rationale, methodology and reproducibility for the PROTECT study
  23. Increased platelet activation in patients with slow coronary flow
  24. Biomarkers of deep venous thrombosis
  25. Thromboembolic complications following a first isolated episode of superficial vein thrombosis: a cross-sectional retrospective study
  26. The impact of factor Xa inhibition on axial dependent arterial thrombus formation triggered by a tissue factor rich surface
  27. New oral Xa and IIa inhibitors: updates on clinical trial results
  28. Spontaneous coronary thrombosis following thrombolytic therapy for acute cardiovascular accident and stroke: a case study
  29. Evaluation of the Alere D-dimer test for point of care testing
  30. Strategies and outcomes of periprocedural bridging therapy with low-molecular-weight heparin in patients with mechanical heart valves
  31. Elevated concentration of placental growth factor (PlGF) and long term risk in patients with acute coronary syndrome in the PROVE IT-TIMI 22 trial
  32. Association between micro particle-tissue factor activity, factor VIII activity and recurrent VTE in patients with acute pulmonary embolism
  33. Methylenetetrahydrofolate reductase (MTHFR) C677T genetic polymorphism and late infarct-related coronary artery patency after thrombolysis
  34. Are surgical patients at risk of venous thromboembolism currently meeting the Surgical Care Improvement Project performance measure for appropriate and timely prophylaxis?
  35. Evaluation of von Willebrand factor and ADAMTS-13 antigen and activity levels in sickle cell disease patients in Kuwait
Search Result: