Authors: Mirko Di Capua Antonio Coppola Rosina Albisinni Antonella Tufano Anna Guida Matteo Nicola Dario Di Minno Ferdinando Cirillo Marcello Loffredo Anna Maria Cerbone
Publish Date: 2009/08/25
Volume: 30, Issue: 1, Pages: 16-22
Abstract
The pathogenesis and treatment of retinal vein occlusions RVO are largely unclear Prevalence of cardiovascular risk factors and of thrombophilic abnormalities was evaluated in 117 patients 61 M 56 F mean age 51 ± 13 years with a history of RVO 62 central CRVO 48 branch BRVO 7 both and in 202 age and sexmatched control subjects Cardiovascular outcome after a mean 82 year followup was recorded for 90 patients Arterial hypertension was significantly more frequent in patients than in controls 649 vs 282 adjusted OR 45 95 CI 24–79 P 00001 as well diabetes mellitus 179 vs 79 P 005 Antithrombin Protein C Protein S and homocysteine levels lupus anticoagulant anticardiolipin antibodies FV G1691A and prothrombin G20210A polymorphisms were comparable in the two groups nor were different according to RVO localization or to the age at event BRVO patients were significantly older 55 ± 9 vs 47 ± 15 years P = 0002 and had higher prevalence of diabetes overweight and hypertension 292 vs 81 833 vs 581 792 vs 565 P always 005 In 58/90 64 patients for whom clinical followup was available new vascular events were recorded coronary/cerebral n = 38 only 22 patients 24 received longterm antiplatelet agents mostly aspirin 100 mg/d with lower but not statistically significant prevalence of overall vascular recurrence 454 vs 706 P = 006 High rate of vascular recurrence is shown in patients with previous RVO in which conventional cardiovascular risk factors play a major role especially in BRVO and in older patients
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