A Network Approach for HIV1 Drug Resistance Preve

Authors: Kouji Harada Yoshiteru Ishida

Publish Date: 2009/9/28

Volume: , Issue: , Pages: 782-788

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Abstract

In AIDS treatments it is an imperative problem to reduce the risk of the drug resistance The previous study discussed which HIV1 gene products are an ideal drug target not to develop drug resistance by applying some ideas of the graph theory and suggested that the drug resistance would not develop if the drug target molecule functions as ”hub” in a chemical network where HIV1 gene products interact directly or indirectly with intracellular agents in a HIV1 host cell The present study fortifies this suggestion in mathematical framework The study develops the expression for a probability of drug resistance developing over the two different types nonhub and hub of drug targets and demonstrates that the hub drug target is more favorable for the drug resistance prevention than the nonhub one

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