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Title of Journal: J Gastroenterol

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Abbravation: Journal of Gastroenterology

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Springer Japan

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Molecular signatures of noncancerous liver tissue can predict the risk for late recurrence of hepatocellular carcinoma

Authors: Tohru Utsunomiya, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Masaki Mori,

Publish Date: 2009/12/08
Volume: 45, Issue:2, Pages: 146-152
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Hepatocellular carcinoma (HCC) is an aggressive malignancy mainly due to tumor metastases or recurrence even after undergoing potentially curative treatment. There are two types of HCC recurrence. The early and late tumor recurrences appear in distinct biological contexts, and their clinical courses are quite different. Therefore, it is important to precisely and distinctly discriminate the risk of each type of HCC recurrence. Many researchers have used DNA microarray technology to reclassify HCC with respect to its malignant potential. Some of these studies successfully identified specific gene-expression signatures derived from the cancerous tissues of HCC for predicting the early recurrence due to intrahepatic metastasis. However, there are no well-defined predictors for late recurrence. Recently, a few studies have focused on the nontumorous portion of liver tissues to predict late recurrence, possibly due to de novo hepatocarcinogenesis based on the idea of “field cancerization.” This study reviewed the possible value of a gene-expression analysis of noncancerous liver tissue to clarify the risk for multicentric late recurrence of HCC. These findings may have important implications for chemopreventive strategies and tailored surveillance programs. Furthermore, this approach may also be applicable to other multifocal tumors, such as head and neck carcinoma.



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Other Papers In This Journal:

  1. Molecular signatures of noncancerous liver tissue can predict the risk for late recurrence of hepatocellular carcinoma
  2. Hepatocyte growth factor stimulates the migration of gastric epithelial cells by altering the subcellular localization of the tight junction protein ZO-1
  3. Factors affecting in-hospital mortality in patients with lower gastrointestinal tract bleeding: a retrospective study using a national database in Japan
  4. Regulation of basal gastric acid secretion by the glycogen synthase kinase GSK3
  5. Effects of transjugular intrahepatic portosystemic shunt on changes in the small bowel mucosa of cirrhotic patients with portal hypertension
  6. Recent advances in autoimmune pancreatitis: concept
  7. Gemcitabine as first-line chemotherapy in elderly patients with unresectable pancreatic carcinoma
  8. Vitamin K deficiency leads to exacerbation of murine dextran sulfate sodium-induced colitis
  9. Association between adherence to evidence-based guidelines for the prescription of non-steroidal anti-inflammatory drugs and the incidence of gastric mucosal lesions in Japanese patients
  10. Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk
  11. Mast cells are involved in the pathogenesis of indomethacin-induced rat enteritis
  12. Noninvasive laboratory tests proposed for predicting cirrhosis in patients with chronic hepatitis C are also useful in patients with non-alcoholic steatohepatitis
  13. Long-term outcomes of patients with metastatic gastric cancer after initial S-1 monotherapy

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