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Publisher
Springer, Berlin, Heidelberg
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Authors: Augusto Parente Rita Berisio Angela Chambery Antimo Di Maro
Publish Date: 2010
Volume: , Issue: , Pages: 79-106
Abstract
The toxicity of plant proteins later identified as ribosomeinactivating proteins RIPs was described more than a century ago and their enzymatic activity was established more than 30 years ago However their physiological role and related biological activities are still uncertain Therefore despite the body of literature research on RIPs is ongoing This review deals with new RIPs being purified sequenced characterized and cloned and an increasing number of 3Dstructures that are determined at high resolution This is the case of the five type 1 RIPs PDS13 PDL1/2 PDL3/4 dioicin 1 and dioicin 2 from seeds and leaves of the ombú tree Phytolacca dioica L native of the grassy pampas of Argentina The data collected so far will contribute to our understanding of important issues of RIP research 1 identifying structural determinants responsible for new enzymatic activities such as the DNA cleaving activity 2 glycosylation and its influence on the catalytic and biological activities 3 cellular localization of endogenous RIPs and their physiological roles
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