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Determinants of Hyperhomocysteinemia After Gastric Bypass Surgery in Obese Subjects

Authors: Séverine Ledoux, Muriel Coupaye, Catherine Bogard, Cristine Clerici, Simon Msika,

Publish Date: 2010/09/03
Volume: 21, Issue:1, Pages: 78-86
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Effectiveness of gastric bypass (GBP) on reduction of vascular risk factors is well established, but GBP induces nutritional deficits that could reduce the cardiovascular benefit of weight loss. Particularly, hyperhomocysteinemia, now clearly identified as a vascular risk factor, has been described after GBP. The aim of this study was to clarify the factors associated with increased homocysteine concentration after GBP.Homocysteine concentration and multiple nutritional parameters were measured in 213 consecutive subjects. One hundred and eight subjects were studied before surgery (control (CT)), 115 one to 6 years after GBP, and 41 both before and 6 months after GBP.Homocysteine concentration did not differ before and after GBP (9.1 ± 3.2 vs 8.6 ± 3.4 μmol/l), but 94% of subjects had been supplemented with a multivitamin preparation after surgery. The nutritional parameters best correlated with homocysteine concentration both before and after GBP were folate and creatinine concentrations (p 



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Other Papers In This Journal:

  1. Determinants of Hyperhomocysteinemia After Gastric Bypass Surgery in Obese Subjects
  2. Preoperative Nutritional Interventions in Morbid Obesity: Impact on Body Weight
  3. Robotic Sleeve Gastrectomy Versus Laparoscopic Sleeve Gastrectomy: a Comparative Study with 200 Patients
  4. Psychological Considerations for Bariatric Surgery among Older Adults
  5. Early Post-operative Complications: Incidence
  6. Changes in Ghrelin Levels Following Bariatric Surgery: Review of the Literature
  7. A Noninvasive Clinical Scoring Model Predicts Risk of Nonalcoholic Steatohepatitis in Morbidly Obese Patients
  8. Effect of Weight Loss following Bariatric Surgery on Myocardial Dispersion of Repolarization in Morbidly Obese Patients
  9. Progress in Implantable Gastric Stimulation: Summary of Results of the European Multi-Center Study
  10. A Retrospective Review of the Medical Management of Hypertension and Diabetes Mellitus Following Sleeve Gastrectomy
  11. Integrated Bioabsorbable Tissue Reinforcement in Laparoscopic Sleeve Gastrectomy
  12. Evaluation of Clinical Outcomes for Gastric Bypass Surgery: Results from a Comprehensive Follow-up Study
  13. Bio-enteric Intragastric Balloon in Obese Patients: A Retrospective Analysis of King Faisal Specialist Hospital Experience
  14. Prognostic Significance of Depressive Symptoms on Weight Loss and Psychosocial Outcomes Following Gastric Bypass Surgery: A Prospective 24-Month Follow-Up Study
  15. Impact of Weight Loss Due to Sleeve Gastrectomy on Shear Stress of the Femoral Vein in Morbid Obesity
  16. Comparison of Volume-controlled and Pressure-controlled Ventilation during Laparoscopic Gastric Banding in Morbidly Obese Patients
  17. Laparoscopic Sleeve Gastrectomy with Duodenojejunal Bypass for the Treatment of Type 2 Diabetes in Non-obese Patients: Technique and Preliminary Results
  18. Laparoscopic Adjustable Gastric Banding: a Prospective Randomized Clinical Trial Comparing 5-Year Results of two Different Bands in 103 Patients
  19. Psychological Correlates of Laparoscopic Adjustable Gastric Band and Gastric Bypass Patients
  20. Preoperative Weight Loss with Intragastric Balloon Decreases the Risk of Significant Adverse Outcomes of Laparoscopic Gastric Bypass in Super-Super Obese Patients
  21. Reconstructive Procedures after Massive Weight Loss

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