Primary tracheobronchial amyloidosis in China Ana

Authors: Liren Ding Wen Li Kai Wang Yahong Chen Hao Xu Huiying Wang Huahao Shen

Publish Date: 2010/11/10

Volume: 30, Issue: 5, Pages: 599-603

PDF Link

Abstract

Primary tracheobronchial amyloidosis TBA is a rare pulmonary disease A systematic review was performed on 64 cases of primary TBA in China and progress in the diagnosis and treatment of this disease is discussed The Chinese biological and medical databases from 1970 to 2010 were searched and 75 cases of complete clinical and pathological data were identified The clinical characteristics of the disease were summarized and longitudinal comparisons were made of diagnostic and treatment methods over time The results showed that the morbidity associated with primary TBA has increased over recent years The clinical manifestations were nonspecific Progressive dyspnea cough and sputum were the most common symptoms The percentage of patients undergoing computed tomography CT scan has increased over the years The bronchoscopy and transbrochial lung biopsy TBLB were usually sufficient to establish the diagnosis Treatment was reported for a total of 44 cases Bronchoscopic NdYAG laser irradiation argon plasma coagulation APC and drugs administration such as steroids and colchicines were reported to be effective in some patients It is concluded that the demographic characteristics and clinical manifestations of primary TBA patients in China are largely consistent with findings reported in other countries Dramatically more cases were reported in recent years mainly due to the extensive application of bronchoscopy since 1990s Chest CT scan provides important clues for the diagnosis of the disease The definite diagnosis was confirmed by bronchoscopic findings and Congo red staining of biopsy specimen Bronchoscopic NdYAG laser irradiation argon plasma coagulation APC and drugs administration such as steroids and colchicines were reported to be effective in some patientsThis project was supported by the grants from Natural Science Foundation of Zhejiang Province No Y2080323 Zhejiang Provincial Science and Technology Administration No 2009R100310 and No 2008C030022 and Health Department of Zhejiang Province No 2009QN010

Keywords: