Cancer Vaccines

Authors: Stephanie Schroter Melanie Hayden Wenxue Ma Nellia Fleurov Neha Rahan Boris R Minev

Publish Date: 2011

Volume: , Issue: , Pages: 257-284

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Abstract

Cancer vaccines are becoming a promising approach to the treatment of cancer This chapter summarizes the scientific background for the design of therapeutic cancer vaccines as well as the challenges in their development The current approaches to the discovery of the tumorassociated antigens as a basis for the new cancer vaccines are reviewed The most promising methods for cancer vaccine development are also discussed In this chapter we categorize the therapeutic cancer vaccines as follows peptide vaccines recombinant viral vaccines DNA vaccines and dendritic cellbased immunotherapy We focus on their advantages and disadvantages and their current uses in the treatment of cancer An uptodate description of the results of cancer vaccine clinical trials is provided We also discuss the future prospects in the design and the utilization of the cancer vaccines

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