Overlap syndrome of autoimmune hepatitis and prima

Authors: Satoshi Nakayama Naoya Murashima

Publish Date: 2011/04/19

Volume: 30, Issue: 2, Pages: 97-99

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Abstract

Although statins are generally welltolerated drugs recent cases of autoimmune hepatitis AIH associated with their use have been reported A 59yearold Japanese man reported with liver damage which appeared one month after beginning treatment with fluvastatin and continued after discontinuation of the drug Although druginduced liver injury was possible positive autoantibody tests antinuclear antibodies 1/1280 antimitochondrial M2 antibodies 21 index value also suggested autoimmune liver disease Liver biopsy findings were consistent with an overlap of autoimmune hepatitis and primary biliary cirrhosis Treatment with prednisone and ursodeoxycholic acid led to a good response In this patient manifestation of AIH and primary biliary cirrhosis overlap syndrome was possibly triggered by statin use Autoimmune liver disease should be considered as a possible diagnosis in patients with evidence of prolonged liver damage after discontinuation of statins

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