Decreased Cyr61 under hypoxia induces extravillous

Authors: Xi Chen Yanyan Liu Xiaoyan Xu Hanping Chen

Publish Date: 2011/04/20

Volume: 31, Issue: 2, Pages: 235-240

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Abstract

During placental development oxygen environment is not only critical for trophoblasts migration and invasion but also fundamental for appropriate placental perfusion Cysteinerich 61 Cyr61 CCN1 was expressed in the extravillous trophoblasts EVTs and decreased in preeclampsia Its regulatory properties in human firsttrimester extravillous trophoblast cell line TEV1 cells upon a low oxygen tension were investigated The present study examined functional changes involved in adaptation to hypoxia of the TEV1 cells using cobalt chloride CoCl2 as hypoxic mimic It was found that hypoxia inhibited growth of TEV1 cells and induced the increase of cell apoptosis P005 The Cyr61 expression in human EVTs was transcriptionally induced by CoCl2 Inappropriate EVTs apoptosis has been implicated in the failure of trophoblasts to fully invade and modify the uterine environment and Cyr61 downregulation potentially leading to preeclampsia

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