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Title of Journal: Ann Hematol

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Abbravation: Annals of Hematology

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Prophylactic intravenous immunoglobulin during autologous haemopoietic stem cell transplantation for multiple myeloma is not associated with reduced infectious complications

Authors: Piers Blombery, H. Miles Prince, Leon J. Worth, Jo Main, Melissa Yang, Erica M. Wood, David A. Westerman,

Publish Date: 2011/06/15
Volume: 90, Issue:10, Pages: 1167-1172
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Patients with multiple myeloma undergoing autologous haemopoietic stem cell transplantation (ASCT) are at high risk for infectious complications. Peri-transplant intravenous immunoglobulin (IVIG) has been used with the aim of reducing these risks. Our retrospective, non-randomised study of peri-transplant IVIG use and effect on infectious complications in 266 ASCTs for myeloma from 2000 to 2009 at a major metropolitan referral centre for haematological malignancies found no difference between those receiving peri-transplant IVIG (0.4 g/kg) (n = 130) and those who were not (n = 110) with regard to bloodstream infections, pneumonia, urinary tract or gastrointestinal infections. When analysed according to pre-transplant therapy (conventional chemotherapy versus novel agents), there was no significant difference in infectious complications between those who did or did not receive peri-transplant IVIG. In conclusion, our study did not show a benefit for the use of peri-transplant IVIG (0.4 g/kg) to reduce infectious complications in a large cohort of patients with myeloma undergoing ASCT. In the absence of data supporting efficacy in this context, there appears to be no benefit in the routine use of IVIG for this purpose.



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Other Papers In This Journal:

  1. In vitro cross-resistance to nucleoside analogues and inhibitors of topoisomerase 1 and 2 in acute myeloid leukemia
  2. Prophylactic intravenous immunoglobulin during autologous haemopoietic stem cell transplantation for multiple myeloma is not associated with reduced infectious complications
  3. Risk factors for poor treatment outcome and central nervous system relapse in diffuse large B-cell lymphoma with bone marrow involvement
  4. A systematic review and meta-analysis of rituximab-based immunochemotherapy for subtypes of diffuse large B cell lymphoma
  5. Therapeutic implication of BAL in patients with neutropenia
  6. Effect of altered iron metabolism on markers of haem biosynthesis and intestinal iron absorption in mice
  7. Glucose-6-phosphate dehydrogenase deficiency and risk of diabetes: a systematic review and meta-analysis
  8. Epidemiological profile of hemoglobinopathies in the Mauritanian population
  9. Haemoglobin Hokusetsu [�52 (D3)] Asp?Gly in German families associated with inclusion body
  10. Suggestion of response evaluation criteria in patients with ocular adnexal mucosa-associated lymphoid tissue lymphoma (OAML)
  11. Porcine antilymphocyte globulin (p-ALG) plus cyclosporine A (CsA) treatment in acquired severe aplastic anemia: a retrospective multicenter analysis
  12. Is the quantity of circulatory cell-free DNA in human plasma and serum samples associated with gender
  13. Reusable terminal tap water filters for nosocomial legionellosis prevention
  14. Association between low uric acid levels and acute graft-versus-host disease
  15. Treatment with monoclonal antibodies in acute lymphoblastic leukemia: current knowledge and future prospects
  16. Telomere elongation and clinical response to androgen treatment in a patient with aplastic anemia and a heterozygous hTERT gene mutation
  17. High-risk AML complicated by pulmonary aspergillosis: successful treatment with nonmyeloablative stem cell transplantation and long-term administration of voriconazole
  18. Perioperative management of a patient with Fechtner syndrome
  19. Hemophagocytosis associated with leukemia: a striking association with juvenile myelomonocytic leukemia
  20. Storage time of red blood cell concentrates and adverse outcomes after cardiac surgery: a cohort study

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