Journal Title
Title of Journal: Curr Breast Cancer Rep
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Abbravation: Current Breast Cancer Reports
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Publisher
Current Science Inc.
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Authors: Karen Lisa Smith Claudine Isaacs
Publish Date: 2011/07/01
Volume: 3, Issue: 3, Pages: 165-171
Abstract
Carriers of deleterious BRCA1 and BRCA2 mutations face an elevated risk of developing breast cancer This risk warrants consideration of prevention interventions Currently the only proven prevention intervention for BRCA mutation carriers is riskreducing surgery Inhibitors of polyADPribose polymerase PARP are a new class of drugs that appear to be effective in treating BRCA mutation–associated cancers and triplenegative breast cancers PARP inhibitors may offer a new approach to breast cancer prevention in BRCA mutation carriers This article reviews current breast cancer prevention interventions for BRCA mutation carriers and discusses the rationale for investigating new chemoprevention agents in this population The mechanism of action of PARP inhibitors and the rationale for studying them in BRCA mutation carriers is reviewed Published clinical trials regarding PARP inhibitors and ongoing research regarding PARP inhibitors and breast cancer prevention are reviewed
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