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Title of Journal: J Comp Physiol A

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Abbravation: Journal of Comparative Physiology A

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Springer-Verlag

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DOI

10.1016/0165-3806(88)90093-4

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1432-1351

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The role of central CB2 cannabinoid receptors on f

Authors: L Emadi H Jonaidi E Hosseini Amir Abad
Publish Date: 2011/09/07
Volume: 197, Issue: 12, Pages: 1143-1147
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Abstract

The endocannabinoids ECBs have diverse physiological functions including the regulation of food intake and metabolism In mammals ECBs regulate feeding primarily through the CB1 receptors within the brain whereas the CB2 receptors are primarily involved in the regulation of immune function by direct action on peripheral immune cells and central glia The central effect of ECBs on feeding behavior has not been studied in nonmammalian species Therefore the present study investigated the effect of CB65 a selective CB2 receptors agonist on food intake in the neonatal chicks In addition the effect of astressin a CRF receptor antagonist on CB65induced food intake was also investigated Intracerebroventricular injection of the CB65 125 μg increased the food intake at 30 and 60min postinjection significantly as compared to the control group Pretreatment with a selective CB2 receptor antagonist AM630 but not astressin significantly attenuated the CB65induced food intake These results suggested that CB2 receptor agonists act on the brain to induce food intake


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