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Title of Journal: Psychopharmacology

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Abbravation: Psychopharmacology

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Lithium, but not valproic acid or carbamazepine, suppresses impulsive-like action in rats

Authors: Yu Ohmura, Iku Tsutsui-Kimura, Haruko Kumamoto, Masabumi Minami, Takeshi Izumi, Taku Yamaguchi, Takayuki Yoshida, Mitsuhiro Yoshioka,

Publish Date: 2011/09/21
Volume: 219, Issue:2, Pages: 421-432
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Following training for the 3-CSRTT, rats were acutely administered lithium chloride (LiCl; 0, 3.2, 10, and 32 mg/kg, i.p.), valproic acid (0, 10, 32, and 100 mg/kg, i.p.), or carbamazepine (0, 10, 20, and 30 mg/kg, i.p.). To assess the anorexic effects of lithium, a simple food consumption test was conducted.LiCl dose-dependently decreased the number of premature responses, an index of impulsive-like action. A high dose of LiCl (32 mg/kg) decreased food consumption, but its anorexic effects were not correlated with the effects of LiCl on premature responses. A moderate dose of LiCl (20 mg/kg) significantly reduced the number of premature responses without affecting motivation-related measures in the 3-CSRTT or the amount of food consumption. Although carbamazepine prolonged reward latency, an index of motivation for food, neither valproic acid nor carbamazepine significantly affected premature responses.It is likely that lithium has a suppressive effect on impulsive action independent of the anorexic effect. Lithium may suppress impulsive behavior and thereby decrease the risk of suicide. The present results could provide an explanation for the antisuicidal effects of lithium and suggest that lithium could be a beneficial treatment for impulsivity-related disorders.



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Other Papers In This Journal:

  1. Lithium
  2. MDMA alters emotional processing and facilitates positive social interaction
  3. Arcaine and MK-801 make recall state-dependent in rats
  4. Roles of D1-like dopamine receptors in the nucleus accumbens and dorsolateral striatum in conditioned avoidance responses
  5. Haloperidol and Risperidone at high concentrations activate an in vitro inflammatory response of RAW 264.7 macrophage cells by induction of apoptosis and modification of cytokine levels
  6. Efficacy and safety of quetiapine extended release monotherapy in bipolar depression: a multi-center
  7. Monoamine transporter gene polymorphisms affect susceptibility to depression and predict antidepressant response
  8. Antipsychotic inductors of brain hypothermia and torpor-like states: perspectives of application
  9. The role of dorsal vs ventral striatal pathways in cocaine-seeking behavior after prolonged abstinence in rats
  10. Euphoriant effects of nicotine in smokers: fact or artifact?
  11. An evaluation of the serotonin system and perseverative
  12. The effect of VMAT2 inhibitor GZ-793A on the reinstatement of methamphetamine-seeking in rats
  13. The effect of VMAT2 inhibitor GZ-793A on the reinstatement of methamphetamine-seeking in rats
  14. Nicotine derived from the electronic cigarette improves time-based prospective memory in abstinent smokers
  15. Dissociable effects of noradrenaline
  16. Varenicline
  17. Efficacy of a glycine transporter 1 inhibitor TASP0315003 in animal models of cognitive dysfunction and negative symptoms of schizophrenia
  18. Positive parenting during childhood moderates the impact of recent negative events on cortisol activity in parentally bereaved youth
  19. Corticosteroid-serotonin interactions in depression: a review of the human evidence
  20. Post-extinction fluoxetine treatment prevents stress-induced reemergence of extinguished fear
  21. Social defeat increases alcohol preference of C57BL/10 strain mice; effect prevented by a CCKB antagonist
  22. Acute administration of lithium
  23. Association of time-dependent changes in mu opioid receptor mRNA
  24. Selective phosphodiesterase inhibitors: a promising target for cognition enhancement
  25. Medications influencing central cholinergic neurotransmission affect saccadic and smooth pursuit eye movements in healthy young adults
  26. Methylphenidate increases cigarette smoking in participants with ADHD
  27. Hormonal
  28. Oral cortisol impairs implicit sequence learning
  29. Influence of nicotine on positive affect in anhedonic smokers

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