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Title of Journal: Support Care Cancer

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Abbravation: Supportive Care in Cancer

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Topical silver sulfadiazine for the prevention of acute dermatitis during irradiation for breast cancer

Authors: Simin Hemati, Omid Asnaashari, Mostafa Sarvizadeh, Behnam Nasiri Motlagh, Mojtaba Akbari, Mina Tajvidi, Abbas Gookizadeh,

Publish Date: 2011/10/19
Volume: 20, Issue:8, Pages: 1613-1618
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A randomized controlled clinical trial was conducted on patients with breast cancer referred for radiotherapy after treatment with mastectomy and chemotherapy. The patients were randomized into the intervention (n = 51) and control (n = 51) groups and were instructed on general skin care during radiotherapy. The intervention group received SSD cream 1%, three times a day, 3 days a week, for 5 weeks during radiotherapy and one week thereafter. A blinded observer assessed the severity of dermatitis weekly (for 6 weeks) and graded it from 0 to 4 according to the Radiation Therapy Oncology Group criteria.The two groups were similar in baseline characteristics. Two patients in the control group discontinued the radiotherapy course because of severe skin injuries (grades 3 and 4). The intervention group encountered significantly less severe dermatitis during radiotherapy compared to the controls. The total score of skin injury was also lower in the intervention group compared with controls (5.49 ± 1.02 vs. 7.21 ± 1.76, p 



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